Antioxidant SMe1EC2 may attenuate the disbalance of sodium homeostasis in the organism induced by higher intake of cholesterol
| Autor: | Norbert Vrbjar, Jana Vlkovicova, Z Kyselova, Štefan Bezek, Lucia Mézešová, Veronika Jendruchová-Javorková, Jana Navarová |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Indoles Antioxidant Pyridines Clinical chemistry medicine.medical_treatment Sodium Clinical Biochemistry chemistry.chemical_element Kidney Hyperlipoproteinemia Type IV Thiobarbituric Acid Reactive Substances Antioxidants Cholesterol Dietary chemistry.chemical_compound Internal medicine medicine Animals Homeostasis Molecular Biology Triglycerides Fenofibrate Chemistry Cholesterol Body Weight Hypertriglyceridemia Proteins Organ Size Cell Biology General Medicine medicine.disease Rats Kinetics Oxidative Stress medicine.anatomical_structure Endocrinology Sodium-Potassium-Exchanging ATPase Glomerular Filtration Rate medicine.drug |
| Zdroj: | Molecular and Cellular Biochemistry. 366:41-48 |
| ISSN: | 1573-4919 0300-8177 |
| Popis: | The study was focused to the influence of higher intake of cholesterol on properties of the renal Na,K-ATPase, a key system in maintaining the homeostasis of sodium in the organism. Feeding for 4 weeks with cholesterol-enriched food for rats afflicted with hereditary hypertriglyceridemia by itself enhanced the activity of Na,K-ATPase, probably as a consequence of higher number of active enzyme molecules as suggested by 32 % increase of V max value. This may be hypothesized as a reason for the increased retention of sodium. Three-week-lasting treatment of animals kept on high cholesterol diet with antioxidant SMe1EC2 in a dose of 10 mg kg−1 day−1 normalized the function of renal Na,K-ATPase to the level comparable in hypertriglyceridemic rats fed with the standard diet. Therefore, our results suggest that the antioxidant SMe1EC2 in the applied dose seems to be effective in the attenuation of cholesterol-induced retention of sodium. Treatment for 3 weeks with Fenofibrate in a dose of 100 mg kg−1 day−1 reversed the function of renal Na,K-ATPase only slightly. |
| Databáze: | OpenAIRE |
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