Impact of acute cellular rejection on coagulation and fibrinolysis biomarkers within the immediate post-operative period in pediatric liver transplantation
| Autor: | Shuji Hishikawa, Jun Mimuro, Akira Ishiwata, Yoichi Sakata, Hideo Kawarasaki, Tsukasa Ohmori, Yuji Kashiwakura, Akiei Hamano, Seiji Madoiwa, Y. Kawano, Koichi Mizuta |
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| Rok vydání: | 2009 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Acute cellular rejection medicine.medical_treatment Liver transplantation Gastroenterology chemistry.chemical_compound Predictive Value of Tests Internal medicine Fibrinolysis Plasminogen Activator Inhibitor 1 Medicine Humans Postoperative Period Post operative Child Blood Coagulation Transplantation business.industry Anticoagulants Blood proteins Surgery Liver Transplantation Logistic Models Coagulation chemistry Plasminogen activator inhibitor-1 Pediatrics Perinatology and Child Health Acute Disease Female business Biomarkers Blood Chemical Analysis Immunosuppressive Agents |
| Zdroj: | Pediatric transplantation. 14(3) |
| ISSN: | 1399-3046 |
| Popis: | We studied restoration of the coagulation and fibrinolysis system in pediatric patients following liver transplantation and biomarkers of blood coagulation and fibrinolysis for suspecting the occurrence of acute cellular rejection. Coagulation activity recovered rapidly within two days following transplantation, but it took approximately 21-28 days for full recovery of the coagulation and fibrinolysis factors synthesized in the liver. PAI-1 levels were significantly higher in patients at the time of acute cellular rejection compared with levels after control of AR, and levels on days 14 and 28 in patients without AR. Plasma protein C and plasminogen levels at the time of rejection were significantly lower than those on day 14 in patients without AR. Statistical analysis suggested that an increase in plasma PAI-1 at a single time point in the post-operative period is a reliable marker among the coagulation and fibrinolysis factors for suspecting the occurrence of acute cellular rejection. These data suggested that appropriate anticoagulation may be required for 14 days after liver transplantation in order to avoid vascular complications and measurement of plasma PAI-1 levels may be useful for suspecting the occurrence of acute cellular rejection in pediatric patients following liver transplantation. |
| Databáze: | OpenAIRE |
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