Accumulation of persistent organic pollutants in consumers of eel from polluted rivers compared to marketable eel

Autor: Ellen Kampman, Wilma T. Steegenga, Ron L.A.P. Hoogenboom, Stefan P.J. van Leeuwen, Dieuwertje E. Kok, Myrthe W. van den Dungen, Albertinka J. Murk, Anuschka Polder
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Delta
Novel Foods & Agrochains
Nutrition and Disease
Health
Toxicology and Mutagenesis
Aquaculture
010501 environmental sciences
Novel Foods & Agroketens
Toxicology
01 natural sciences
Hydroxylated PCBs
BU Contaminants & Toxins
Voeding
Metabolisme en Genomica
Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]
Consumer health
Adverse health effect
Voeding en Ziekte
Bioassay
BU Toxicology
Novel Foods & Agrochains
Netherlands
Eels
BU Toxicology
eel (Anguilla anguilla)
General Medicine
Middle Aged
Contamination
Polychlorinated Biphenyls
Pollution
Metabolism and Genomics
BU Toxicologie
Novel Foods & Agroketens
Metabolisme en Genomica
Nutrition
Metabolism and Genomics
Milieutechnologie
Biological Assay
Environmental Monitoring
Adult
BU Toxicologie
BU Contaminanten & Toxines
Biology
Dioxins
Gas Chromatography-Mass Spectrometry
03 medical and health sciences
Marine Animal Ecology
Voeding
Rivers
PFOS
Animals
Humans
CALUX
Persistent organic pollutants (POPs)
Nutrition
VLAG
Aged
0105 earth and related environmental sciences
Pollutant
Maximum level
business.industry
Mariene Dierecologie
Anguilla
030104 developmental biology
Environmental Technology
Environmental Pollution
business
Water Pollutants
Chemical
Zdroj: Environmental Pollution, 219, pp. 80-88
Environmental Pollution 219 (2016)
Environmental Pollution, 219, 80-88
ISSN: 0269-7491
Popis: Contains fulltext : 182422.pdf (Publisher’s version ) (Closed access) Globally, many river sediments are seriously contaminated with persistent organic pollutants (POPs) known to accumulate in aquatic food. In the Netherlands, toxicological risks of human exposure to dioxins and dioxin-like compounds led to a ban on eel fishing in the Rhine-Meuse delta. The aim of this study is to investigate differences in serum POP levels in consumers of eel from high-polluted areas and consumers of eel from low-polluted areas or aquaculture. In total 80 Dutch men were included, aged 40-70 years, with a habitual eel consumption of at least one portion (150 g) per month. Total levels of dioxins and dioxin-like compounds were measured in serum of all participants with the DR CALUX bioassay, validated with GC-MS. For a subgroup of 38 participants extensive POP measurements were performed. We revealed that consumption of eel from polluted rivers resulted in 2.5 and up to 10 times increased levels of dioxins and polychlorinated biphenyls (PCBs) respectively compared to controls. The highest PCB levels were detected for PCB 153, with a median level of 896 ng/g lipid and a maximum level of 5000 ng/g lipid in the high-exposed group. Furthermore, hydroxylated PCB metabolites (OH-PCBs: sum of 4-OH-CB107, 4-OH-CB146, 4'-OH-CB172, and 4-OH-CB187) were 8 times higher in men who consumed eel from polluted areas, and detected at levels (median 4.5 ng/g ww) reported to cause adverse health effects. Also, the majority of the perfluoroalkyl substances (PFASs) were significantly higher in consumers of eel from pullulated areas. In conclusion, this study is the first to reveal that (past) consumption of eel from polluted rivers resulted in high body burdens of dioxins, PCBs, OH-PCBs and PFASs. We confirmed the predictions made in a former risk assessment, and the high levels of dioxins and dioxin-like compounds as well as the OH-PCBs are of health concern.
Databáze: OpenAIRE
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