The development of a [211at]-astatinated endoradiotherapeutic drug: Part I. Localization by α-particle autoradiography in a murine tumor model
| Autor: | Ian Brown, R. N. Carpenter, Joseph S. Mitchell |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty medicine.medical_treatment Rectum Mice In vivo medicine Animals Distribution (pharmacology) Radiology Nuclear Medicine and imaging Radiation Lung Rectal Neoplasms business.industry Alkaline Phosphatase Alpha Particles medicine.disease Mice Inbred C57BL Radiation therapy medicine.anatomical_structure Oncology Cancer research Autoradiography Adenocarcinoma Bone marrow business Astatine Intracellular |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 23:563-572 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/0360-3016(92)90012-7 |
| Popis: | α-particle track autoradiography has been used to define the in vivo cellular and intracellular distribution of radioactivity from the potential high linear energy transfer endoradiotherapeutic drug, 6-[ 211 At]-astato-2-methyl-1,4-naphthoquinol bis(diphosphate) in tumor and relevant critical normal tissues of mice bearing a transplanted murine rectal carcinoma. A strikingly selective uptake of this compound into tumor cells, particularly into specific tumor cell nuclei, has been demonstrated. Its localization in certain tumor cells appears to depend on the presence of an onco-product, in this case an alkaline phosphatase isoenzyme, which is synthesized in some tumor cells and to which the compound targets. In curable tumors, it selectively concentrates in cells which may be regarded as tumor stem cells. There is low uptake into normal cells, particularly those in bone marrow, colon, and lung, where its sequestration is mainly extranuclear. |
| Databáze: | OpenAIRE |
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