α-Fe2O3@Pt heterostructure particles to enable sonodynamic therapy with self-supplied O2 and imaging-guidance
| Autor: | Congkun Xie, Yike Fu, Yongjun Wu, Xiujun Cai, Xiang Li, Gonglin Fan, Qiang Zheng, Gaorong Han, Tian Zhang, Yifan Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Materials science
Ultrasonic Therapy Schottky barrier Biomedical Engineering Contrast Media Pharmaceutical Science Medicine (miscellaneous) Nanoparticle Antineoplastic Agents Apoptosis Bioengineering Nanotechnology Applied Microbiology and Biotechnology Theranostic Nanomedicine Mice Self-supplied oxygen Cell Line Tumor Medical technology Animals Tumor theranostic R855-855.5 Magnetite Nanoparticles Platinum Ultrasonography Mice Inbred BALB C Research Imaging guidance Sonodynamic therapy Tumor therapy Heterojunction Heterostructure Ultrasound imaging Molecular Medicine Female Composite nanoparticles TP248.13-248.65 Biotechnology |
| Zdroj: | Journal of Nanobiotechnology Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-14 (2021) |
| ISSN: | 1477-3155 |
| DOI: | 10.1186/s12951-021-01105-x |
| Popis: | Sonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is severely hindered by the intrinsic hypoxia of solid tumor and the lack of smart design in material band structure. Here in study, fine α-Fe2O3 nanoparticles armored with Pt nanocrystals (α-Fe2O3@Pt) was investigated as an alternative SDT agent with ingenious bandgap and structural design. The Schottky barrier, due to its unique heterostructure, suppresses the recombination of sono-induced electrons and holes, enabling superior ROS generation. More importantly, the composite nanoparticles may effectively trigger a reoxygenation phenomenon to supply sufficient content of oxygen, favoring the ROS induction under the hypoxic condition and its extra role played for ultrasound imaging. In consequence, α-Fe2O3@Pt appears to enable effective tumor inhibition with imaging guidance, both in vitro and in vivo. This study has therefore demonstrated a highly potential platform for ultrasound-driven tumor theranostic, which may spark a series of further explorations in therapeutic systems with more rational material design. Graphical Abstract |
| Databáze: | OpenAIRE |
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