Mild COVID-19 infection despite chronic B cell depletion in a patient with aquaporin-4-positive neuromyelitis optica spectrum disorder
| Autor: | Jaime Imitola, Enrique Ballesteros, Marina A. Creed, L. John Greenfield |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Multiple Sclerosis
coronaviruses Clinical Neurology Disease Neuromyelitis Optica Spectrum Disorder (NMOSD) medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Medicine Humans Immunologic Factors 030212 general & internal medicine Coronavirus Autoantibodies Aquaporin 4 B-Lymphocytes Neuromyelitis optica SARS-CoV-2 business.industry pandemic Multiple sclerosis Neuromyelitis Optica COVID-19 General Medicine Middle Aged medicine.disease Pneumonia Neurology Immunology Rituximab Female Neurology (clinical) business Cytokine storm 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Multiple Sclerosis and Related Disorders |
| ISSN: | 2211-0348 |
| DOI: | 10.1016/j.msard.2020.102199 |
| Popis: | Coronavirus disease 2019 (COVID-19) is caused by the novel coronavirus SARS-CoV-2, which affects the lung and other organs. After an incubation period of 3-14 days, the infection presents with symptoms of variable severity, from mild flu-like disease to severe pneumonia and cytokine storm with increased mortality. Immunosuppressed patients may have higher risk of adverse outcomes; hence, there is an urgent need to evaluate the immune response and clinical outcomes of SARS-CoV-2 infection in these patients. Here, we report a 59-year-old woman with aquaporin-4-positive (AQPR4+) neuromyelitis Optica treated with rituximab who developed mild respiratory symptoms with COVID-19, despite B cell depletion at the time of infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect