HBV and HIV/HBV Infected Patients Have Distinct Immune Exhaustion and Apoptotic Serum Biomarker Profiles
| Autor: | Meina Liang, Norah J. Shire, Enass A. Abdel-hameed, Kenneth E. Sherman, Mark T. Esser, Mohamed T. Shata, Li Yu, Esther Song, Susan D. Rouster |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
lcsh:Immunologic diseases. Allergy Cirrhosis medicine.medical_treatment Immunology medicine.disease_cause Article Fas ligand 03 medical and health sciences Liver disease 0302 clinical medicine PD-1 HBV lcsh:Pathology Immunology and Allergy Medicine Molecular Biology 030304 developmental biology Hepatitis B virus 0303 health sciences business.industry virus diseases HIV sFas medicine.disease 3. Good health Infectious Diseases Cytokine Hepatocellular carcinoma TNF-α Coinfection Biomarker (medicine) Immune exhaustion markers coinfection HBV/HIV business lcsh:RC581-607 030215 immunology lcsh:RB1-214 |
| Zdroj: | Pathogens and Immunity, Vol 4, Iss 1, Pp 39-65 (2019) Pathogens & immunity |
| ISSN: | 2469-2964 |
| Popis: | Background: Hepatitis B virus (HBV) infection is a leading cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma worldwide. Due to their shared routes of transmission, approximately 10% of HIV-infected patients worldwide are chronically coinfected with HBV. Additionally, liver disease has become a major cause of morbidity and mortality in HBV/HIV coinfected patients due to prolonged survival with the success of antiretroviral therapy. The relationship between immune exhaustion markers (PD-1/PD-L1) and apoptotic markers such as Fas/FasL, TGFβ1, TNF-α, and Th1/Th2 cytokines are not clearly delineated in HBV/HIV coinfection.Methods: Levels of soluble Fas/FasL, TGFβ1, TNF-α, and sPD-1/sPD-L1 as well as Th1 and Th2 cytokines were evaluated in the sera of HBV-monoinfected (n=30) and HBV/HIV-coinfected (n=15) patients and compared to levels in healthy controls (n=20).Results: HBV-monoinfected patients had significantly lower levels of the anti-inflammatory cytokine IL-4 (P |
| Databáze: | OpenAIRE |
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