Assessment of stress levels in girls with central precocious puberty before and during long-acting gonadotropin-releasing hormone agonist treatment: a pilot study
| Autor: | Danielle S Bessa, Tais A S Menk, Delanie B. Macedo, Marlene Inácio, Berenice B. Mendonca, Ana Claudia Latronico, Vinicius Nahime Brito |
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| Rok vydání: | 2017 |
| Předmět: |
Agonist
medicine.medical_specialty Adolescent medicine.drug_class Endocrinology Diabetes and Metabolism Central precocious puberty Puberty Precocious Physiology Pilot Projects 030209 endocrinology & metabolism Stress level Gonadotropin-Releasing Hormone 03 medical and health sciences 0302 clinical medicine Endocrinology 030225 pediatrics Gonadotropin-releasing hormone agonist Internal medicine Humans Medicine Psychological testing Child Triptorelin Pamoate business.industry Luteolytic Agents Treatment Outcome Long acting Pediatrics Perinatology and Child Health Female business Sexual precocity Stress Psychological Hormone |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 30:657-662 |
| ISSN: | 2191-0251 0334-018X |
| Popis: | Background: The objective of the study was to determine the stress levels of girls with central precocious puberty (CPP) before and during treatment with a long-acting gonadotropin-releasing hormone agonist (GnRHa). Methods: The Child Stress Scale (CSS) was used for 10 unrelated girls with CPP before and after the first year of GnRHa treatment. The CSS is divided into four subscales (physical, psychological, psychological with depressive component and psychophysiological reactions). Through a quantitative analysis, it is possible to classify stress into four stages: alarm, resistance, near-exhaustion and exhaustion. Results: At diagnosis, 90% of the girls showed stress levels scores at the alarm or resistance stage on at least one subscale, mostly in terms of physical and psychological reactions. The mean total stress score was significantly higher before when compared to after GnRHa treatment (43.4±15.6 vs. 28.9±9.7; p Conclusions: Higher stress levels were a common finding in girls with CPP before treatment. The significant stress level reduction after pubertal suppression reinforces the idea that sexual precocity is a stressful condition in children. The CSS might be a useful tool for psychological assessment of patients with CPP. |
| Databáze: | OpenAIRE |
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