In the Right Place at the Right Time: Regulation of Cell Metabolism by IP3R-Mediated Inter-Organelle Ca2+ Fluxes
| Autor: | Eduardo Silva-Pavez, Cesar Cardenas, Andrea Puebla-Huerta, Ulises Ahumada-Castro, Galdo Bustos, Alenka Lovy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Anabolism
Mini Review Mitochondrion Cell and Developmental Biology chemistry.chemical_compound Lysosome Organelle medicine Inositol lcsh:QH301-705.5 inositol triphosphate (IP3) receptors calcium Catabolism Chemistry Endoplasmic reticulum Cell Biology Cell biology mitochondria endoplasmic reticulum medicine.anatomical_structure Cell metabolism lcsh:Biology (General) lysosome IP3Rs metabolism Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology, Vol 9 (2021) Frontiers in Cell and Developmental Biology |
| ISSN: | 2296-634X |
| DOI: | 10.3389/fcell.2021.629522 |
| Popis: | In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (IP3R)-mediated calcium (Ca2+) release plays a central role. Recent evidence suggests that IP3R isoforms participate in synthesis and degradation pathways. This minireview will summarize the current findings in this area, emphasizing the critical role of Ca2+communication on organelle function as well as catabolism and anabolism, particularly in cancer. |
| Databáze: | OpenAIRE |
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