AIE-based theranostic systems for detection and killing of pathogens
| Autor: | Zheng Zhao, Ryan T. K. Kwok, Liang Luo, Jacky Wing Yip Lam, Ben Zhong Tang, Zaiyu Wang, Xuewen He, Ling-Hong Xiong |
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| Rok vydání: | 2019 |
| Předmět: |
Pathogen detection
Macromolecular Substances Medicine (miscellaneous) Multifunctional Nanoparticles Review 02 engineering and technology Computational biology Biology 010402 general chemistry medicine.disease_cause Communicable Diseases Sensitivity and Specificity 01 natural sciences Theranostic Nanomedicine Human health Anti-Infective Agents medicine Animals Humans Pharmacology Toxicology and Pharmaceutics (miscellaneous) Pathogen Colony counting Fluorescent Dyes Photosensitizing Agents Diagnostic Tests Routine Optical Imaging Diagnostic test Pathogenic bacteria 021001 nanoscience & nanotechnology 0104 chemical sciences 0210 nano-technology |
| Zdroj: | Theranostics |
| ISSN: | 1838-7640 |
| DOI: | 10.7150/thno.31844 |
| Popis: | Pathogenic bacteria, fungi and viruses pose serious threats to the human health under appropriate conditions. There are many rapid and sensitive approaches have been developed for identification and quantification of specific pathogens, but many challenges still exist. Culture/colony counting and polymerase chain reaction are the classical methods used for pathogen detection, but their operations are time-consuming and laborious. On the other hand, the emergence and rapid spread of multidrug-resistant pathogens is another global threat. It is thus of utmost urgency to develop new therapeutic agents or strategies. Luminogens with aggregation-induced emission (AIEgens) and their derived supramolecular systems with unique optical properties have been developed as fluorescent probes for turn-on sensing of pathogens with high sensitivity and specificity. In addition, AIE-based supramolecular nanostructures exhibit excellent photodynamic inactivation (PDI) activity in aggregate, offering great potential for not only light-up diagnosis of pathogen, but also image-guided PDI therapy for pathogenic infection. |
| Databáze: | OpenAIRE |
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