Persistent cutaneous insulin allergy resulting from high-molecular-weight insulin aggregates
| Autor: | Terence M Phillips, Malcolm L Steiner, Robert E Ratner |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Allergy
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Lymphocyte Stimulation Lymphocyte Activation Drug Hypersensitivity In vivo Internal medicine Internal Medicine medicine Concanavalin A Humans Insulin Skin biology business.industry Immunochemistry medicine.disease In vitro Molecular Weight medicine.anatomical_structure Endocrinology Toxicity biology.protein business |
| Zdroj: | Diabetes. 39(6) |
| ISSN: | 0012-1797 |
| Popis: | Cutaneous insulin allergy remains a clinical problem despite the use of highly purified human insulins. We used in vitro lymphocyte-transformation studies to examine the reactivity of various insulin formulations in diabetic patients with (n = 4) and without (n = 8) cutaneous allergies. Nonspecific response to concanavalin A demonstrated a >40-fold response in both groups. Control patients did not respond to the addition of commercial insulin preparations (stimulation index [SI] |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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