Imunoglobulinas do líquido cefalorraqueano no recém-nascido
| Autor: | Bertha R. da Luz, José Antonio Livramento, Antonio Spina-França, Luís dos Ramos Machado |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Pathology biology Chemistry Day of life Normal values Blood proteins lcsh:RC321-571 Endocrinology Cerebrospinal fluid Neurology Internal medicine medicine biology.protein Neurology (clinical) Igg index Antibody lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Nephelometry |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Vol 43, Iss 2, Pp 147-153 (1985) Arquivos de Neuro-Psiquiatria v.43 n.2 1985 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO Arquivos de Neuro-Psiquiatria, Volume: 43, Issue: 2, Pages: 147-153, Published: JUN 1985 |
| ISSN: | 0004-282X |
| DOI: | 10.1590/s0004-282x1985000200004 |
| Popis: | Foram estudadas as imunoglobulinas IgG, IgA e IgM no soro e no LCR de 36 recém-nascidos no segundo dia de vida. Para caracterização prévia da normalidade, tanto para as amostras de soro, como para as amostras de LCR, foram realizados estudos comparativos com dados já estabelecidos anteriormente no nosso meio. O estudo das imunoglobulinas no soro e no LCR foram realizados por dois métodos: imunodifusão radial e nefelometria. Os valores encontrados (média ± desvio padrão) são os que se seguem (mg/dl). Para o soro: pelo método de IDR IgG 1346 ± 299,1; IgM 10,4 ± 2,26; IgA 1,1 ± 1,06; pelo método de nefelometria IgG 1372 ± 319,7; IgM 10,6 ± 4,10; IgA 1,5 ± 0,31. Nas amostras de LCR ambos os métodos não permitiram detectar IgA e IgM; IgG foi detectada por ambos e os valores observados (média ± desvio padrão) foram (mg/dl): por imunodifusão radial 11,1 ± 2,52; por nefelometria 9,6 ± 7,04. Foram estudadas também as relações e o índice de IgG; deles, salienta-se que ò índice de IgG, apresenta valores normais de 0,5 ± 0,14. Immunoglobulins IgG, IgA and IgM were studied in serum and cerebrospinal fluid (CSF) samples from 36 newborn infants in the second day of life. According to parameters previously established in the same laboratory for normal newborn infants, serum proteins were normal in all samples and CSF composition was normal as to blood pigments, cells, total proteins and protein fractions in all samples. Immunoglobulins concentrations were determined by two methods: radial immunodifusion (RID) and nephelometry. Concentrations found (mean ± standard deviation) were as follows (mg/dl). Serum: through the RID method IgG 1346 ± 299.1, IgM 10.4 ± 2.26, IgA 1.1 ± 1.06; through nephelometry IgG 1372 ± 319.7, IgM 10.6 ± 4.10, IgA 1.5 ± 0.31. Cerebrospinal fluid: IgA and IgM were not detected by the methods employed; IgG was detected by both methods, and values were 11.1 ± 2.52 by RID and 9.6 ± 7.04 by nephelometry. IgG relations and IgG index were also evaluated; values of the IgG index (0.5 ± 0.14) are emphasized. Considerations are made in order to point out data obtained as to characterize normal values for immunoglobulins in the cerebrospinal fluid of normal newborn infants. |
| Databáze: | OpenAIRE |
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