Timing and regimen of puberty induction in children with hypogonadism: a survey on the practice in Arab countries
| Autor: | Abdelhadi Habeb, Asma Deeb, Rasha T. Hamza, Sarah Hussein Alani, Hussain Al Saffar |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent medicine.drug_class Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Time-to-Treatment Human chorionic gonadotropin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Surveys and Questionnaires Breakthrough bleeding Diabetes mellitus Turner syndrome medicine Humans 030212 general & internal medicine Practice Patterns Physicians' Child Progesterone business.industry Hypogonadism Puberty Estrogens Prognosis medicine.disease Arabs Conjugated estrogen Regimen chemistry Estrogen Pediatrics Perinatology and Child Health Intramuscular testosterone Female Progestins medicine.symptom business Follow-Up Studies |
| Zdroj: | Journal of Pediatric Endocrinology and Metabolism. 33:1197-1202 |
| ISSN: | 2191-0251 0334-018X |
| Popis: | Objectives There are some variations in the practice of puberty induction between different regions; however, data from Arab countries are lacking. We aimed to survey the practice of pediatric endocrinologists in Arab countries on the timing and regimen for puberty induction in girls and boys with hypogonadism. Methods An online questionnaire was emailed to physicians registered in the Arab Society for Paediatric Endocrinology and Diabetes. Results In total, 106 replies from 17 countries were received. In non Turner syndrome (TS) girls, puberty was induced by 49.4% of participants at 12–13 years and by 32.5% at ≥14 years. Ethinyl estradiol and conjugated estrogen were the most popular preparations used (29.7 and 16.6%, respectively). Of the participants, 60% introduce progesterone either at 2–3 years after starting estrogen or following a significant breakthrough bleeding on estrogen. In girls with TS, 84.2% of participants prescribed estrogen to those aged 11 years and older (51.5% at 11–12 years) and 5.3% prescribed it to those at the prepubertal age. In boys, 57.3% of participants induce at ≥14 years, 80.6% use intramuscular testosterone and 46.5% start with 50 mg/kg/month. Human chorionic gonadotropin is more used in non-Gulf Arab countries (18.2 vs. 2.9%; p 0.036) with a trend of using oral testosterone undecanoate in Gulf states (12.2 vs. 2.0%; p 0.051). Conclusions We describe the approach to puberty induction in boys and girls among pediatric endocrinologists in Arab countries. The observed variation in practice would be useful in developing regional consensus guidelines on puberty induction in children with hypogonadism. |
| Databáze: | OpenAIRE |
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