Molecular biology and pathogenesis of animal lentivirus infections
| Autor: | M C Zink, Janice E. Clements |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Gene Expression Regulation
Viral Microbiology (medical) Epidemiology Visna virus animal diseases viruses Genome Viral medicine.disease_cause Tropism Virus Pathogenesis medicine Animals General Immunology and Microbiology biology Genetically modified virus Lentivirus Public Health Environmental and Occupational Health virus diseases Lentivirus Infections Simian immunodeficiency virus biology.organism_classification Virology Infectious Diseases Lentiviruses Ovine-Caprine Immunology Simian Immunodeficiency Virus Viral disease Research Article |
| Zdroj: | Clinical Microbiology Reviews. 9:100-117 |
| ISSN: | 1098-6618 0893-8512 |
| DOI: | 10.1128/cmr.9.1.100 |
| Popis: | Lentiviruses are a subfamily of retroviruses that are characterized by long incubation periods between infection of the host and the manifestation of clinical disease. Human immunodeficiency virus type 1, the causative agent of AIDS, is the most widely studied lentivirus. However, the lentiviruses that infect sheep, goats, and horses were identified and studied prior to the emergence of human immunodeficiency virus type 1. These and other animal lentiviruses provide important systems in which to investigate the molecular pathogenesis of this family of viruses. This review will focus on two animal lentivirus models: the ovine lentivirus visna virus; and the simian lentivirus, simian immunodeficiency virus. These animal lentiviruses have been used to examine, in particular, the pathogenesis of lentivirus-induced central nervous system disease as models for humans with AIDS as well as other chronic diseases. |
| Databáze: | OpenAIRE |
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