Application of a cost-effectiveness analysis of pathogen-specific vaccines against gastroenteritis to a military population in a developing country setting
| Autor: | Mark S. Riddle, Dawn Quigley, Aaron Tallant, Andrew J. Mirelman, Robert H. Gilman, Regan Stiegmann, Rosio G Guerra, Sarah-Blythe Ballard |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Cost-Benefit Analysis 030231 tropical medicine Population Developing country medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Environmental health Peru medicine Humans 030212 general & internal medicine education Developing Countries health care economics and organizations Vaccines education.field_of_study General Veterinary General Immunology and Microbiology business.industry Incidence (epidemiology) Campylobacter Public Health Environmental and Occupational Health Cost-effectiveness analysis Gastroenteritis Diarrhea Military Personnel Models Economic Infectious Diseases Norovirus Molecular Medicine medicine.symptom business Infectious gastroenteritis |
| Zdroj: | Vaccine |
| ISSN: | 0264-410X |
| DOI: | 10.1016/j.vaccine.2020.01.075 |
| Popis: | Vaccine implementation planning in low- and middle-income countries (LMIC) often focuses on children without considering special adult populations. We adapted an economic model developed by the United States Department of Defense (DoD) to evaluate the cost-effectiveness of vaccine acquisition strategies for Campylobacter-, ETEC-, Shigella-, and norovirus-associated gastroenteritis. We compared implementation costs with current medical management in the Peruvian armed forces, a special population of low- and middle-income (LMIC) adults with a high incidence of infectious gastroenteritis. Pathogen-specific vaccine implementation resulted in calculated cost-effectiveness ratio (CER) per duty day lost averted (CER(DDL)) of $13,741; $1,272; $301; and $803, and a CER per diarrhea day averted of $2,130; $215; $51; and $199 for Campylobacter, ETEC, Shigella, and norovirus, respectively. These estimates compare favorably to CER(DDL) estimates from high-income military population and suggest that implementing vaccines gastroenteritis may be cost-effective in the Peruvian military population. |
| Databáze: | OpenAIRE |
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