Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2
Autor: | Silvestri, Barrowdale, V., DMulligan A. M., C, dEmail, Author, Neuhausen, eEmail Author, S. L., Fox, fEmail Author, S., Karlan, gEmail Author, B. Y., Mitchell G., H, iEmail, Author, James P., H, Thull, jEmail Author, D. L., Zorn, jEmail Author, K. K., Carter, kEmail Author, N. J., Nathanson, lEmail Author, K. L., Domchek, lEmail Author, S. M., Rebbeck, mEmail Author, T. R., Ramus, nEmail Author, S. J., Nussbaum, oEmail Author, R. L., Olopade, pEmail Author, O. I., Rantala, qEmail Author, J., Yoon, S. -Y., R, sEmail, Author, Caligo, tEmail Author, M. A., Spugnesi, tEmail Author, L., Bojesen, uEmail Author, A., Pedersen, vEmail Author, I. S., Thomassen, wEmail Author, M., Jensen, xEmail Author, U. B., Toland, yEmail Author, A. E., Senter, zEmail Author, L., Andrulis I. L., D, abEmail, Author, Glendon, aaEmail Author, G., Hulick, acEmail Author, P. J., Imyanitov, adEmail Author, E. N., Greene, aeEmail Author, M. H., Mai, aeEmail Author, P. L., Singer, afEmail Author, C. F., Rappaport-Fuerhauser, afEmail Author, C., Kramer, agEmail Author, G., Vijai, ahEmail Author, J., Offit, ahEmail Author, K., Robson, aiEmail Author, M., Lincoln, ahEmail Author, A., Jacobs, ahEmail Author, L., Machackova, ajEmail Author, E., Foretova, akEmail Author, L., Navratilova, ajEmail Author, M., Vasickova, ajEmail Author, P., Couch, F. J., Al, amEmail, Author, Hallberg, amEmail Author, E., Ruddy, anEmail Author, K. J., Sharma, aoEmail Author, P., Kim, apEmail Author, S. -W., Teixeira, M. R., Aq, arEmail, Author, Pinto, aqEmail Author, P., Montagna, asEmail Author, M., Matricardi, asEmail Author, L., Arason, atEmail Author, A., Johannsson, auEmail Author, O. T., Barkardottir, atEmail Author, R. B., Jakubowska, avEmail Author, A., Lubinski, avEmail Author, J., Izquierdo, awEmail Author, A., Pujana, axEmail Author, M. A., Balmaña, ayEmail Author, J., Diez, azEmail Author, O., Ivady, baEmail Author, G., Papp, bbEmail Author, J., Olah, bbEmail Author, E., Kwong, Bc, A., bdEmail, Author, Nevanlinna, beEmail Author, H., Aittomäki, bfEmail Author, K., Perez, Segura, bgEmail Author, P., Caldes, bhEmail Author, T., Van, Maerken, biEmail Author, T., Poppe, biEmail Author, B., Claes, biEmail Author, K. B. M., Isaacs, bjEmail Author, C., Elan, bkEmail Author, C., Lasset, Bl, C., bmEmail, Author, Stoppa-Lyonnet, Bk, D., bnEmail, Author, Barjhoux, boEmail Author, L., Belotti, bkEmail Author, M., Meindl, bpEmail Author, A., Gehrig, bqEmail Author, A., Sutter, brEmail Author, C., Engel, bsEmail Author, C., Niederacher, btEmail Author, D., Steinemann, buEmail Author, D., Hahnen, bvEmail Author, E., Kast, bwEmail Author, K., Arnold, bxEmail Author, N., Varon-Mateeva, byEmail Author, R., Wand, bzEmail Author, D., Godwin, caEmail Author, A. K., Evans, cbEmail Author, D. G., Frost, bEmail Author, D., Perkins, bEmail Author, J., Adlard, ccEmail Author, J., Izatt, cdEmail Author, L., Platte, ceEmail Author, R., Eeles, cfEmail Author, R., Ellis, bEmail Author, S., Hamann, cfEmail Author, U., Garber, cgEmail Author, J., Fostira, chEmail Author, F., Fountzilas, ciEmail Author, G., Pasini, Cj, B., ckEmail, Author, Giannini, aEmail Author, G., Rizzolo, aEmail Author, P., Russo, clEmail Author, A., Cortesi, cmEmail Author, L., Papi, Laura, cnEmail Author, L., Varesco, coEmail Author, L., Palli, cpEmail Author, D., Zanna, cpEmail Author, I., Savarese, cqEmail Author, A., Radice, crEmail Author, P., Manoukian, csEmail Author, S., Peissel, csEmail Author, B., Barile, ctEmail Author, M., Bonanni, ctEmail Author, B., Viel, cuEmail Author, A., Pensotti, Cv, V., cwEmail, Author, Tommasi, cxEmail Author, S., Peterlongo, cvEmail Author, P., Weitzel, cyEmail Author, J. N., Osorio, Cz, A., daEmail, Author, Benitez, Da, J., dcEmail, Author, McGuffog, bEmail Author, L., Healey, ddEmail Author, S., Gerdes, deEmail Author, A. -M., Ejlertsen, dfEmail Author, B., Hansen, dgEmail Author, T. V. O., Steele, eEmail Author, L., Ding, eEmail Author, Y. C., Tung, dhEmail Author, N., Janavicius, diEmail Author, R., Goldgar, djEmail Author, D. E., Buys, dkEmail Author, S. S., Daly, dlEmail Author, M. B., Bane, dmEmail Author, A., Terry, dnEmail Author, M. B., John, doEmail Author, E. M., Southey, dpEmail Author, M., Easton, bEmail Author, D. F., Chenevix-Trench, ddEmail Author, G., Antoniou, bEmail Author, A. C., Ottini, Papi, L |
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Přispěvatelé: | Pathology, Department of Obstetrics and Gynecology, Clinicum, Medicum, Department of Medical and Clinical Genetics, Silvestri, Valentina, Barrowdale, Daniel, Mulligan, Anna Marie, Neuhausen, Susan L., Fox, Stephen, Karlan, Beth Y., Mitchell, Gillian, James, Paul, Thull, Darcy L., Zorn, Kristin K., Carter, Natalie J., Nathanson, Katherine L., Domchek, Susan M., Rebbeck, Timothy R., Ramus, Susan J., Nussbaum, Robert L., Olopade, Olufunmilayo I., Rantala, Johanna, Yoon, Sook-Yee, Caligo, Maria A., Spugnesi, Laura, Bojesen, Ander, Pedersen, Inge Sokilde, Thomassen, Mad, Jensen, Uffe Birk, Toland, Amanda Ewart, Senter, Leigha, Andrulis, Irene L., Glendon, Gord, Hulick, Peter J., Imyanitov, Evgeny N., Greene, Mark H., Mai, Phuong L., Singer, Christian F., Rappaport-Fuerhauser, Christine, Kramer, Gero, Vijai, Joseph, Offit, Kenneth, Robson, Mark, Lincoln, Anne, Jacobs, Lauren, Machackova, Eva, Foretova, Lenka, Navratilova, Marie, Vasickova, Petra, Couch, Fergus J., Hallberg, Emily, Ruddy, Kathryn J., Sharma, Priyanka, Kim, Sung-Won, Teixeira, Manuel R., Pinto, Pedro, Montagna, Marco, Matricardi, Laura, Arason, Adalgeir, Johannsson, Oskar Th, Barkardottir, Rosa B., Jakubowska, Anna, Lubinski, Jan, Izquierdo, Angel, Pujana, Miguel Angel, Balmaña, Judith, Diez, Orland, Ivady, Gabriella, Papp, Jano, Olah, Edith, Kwong, Ava, Nevanlinna, Heli, Aittomäki, Kristiina, Perez Segura, Pedro, Caldes, Trinidad, Van Maerken, Tom, Poppe, Bruce, Claes, Kathleen B.M., Isaacs, Claudine, Elan, Camille, Lasset, Christine, Stoppa-Lyonnet, Dominique, Barjhoux, Laure, Belotti, Muriel, Meindl, Alfon, Gehrig, Andrea, Sutter, Christian, Engel, Christoph, Niederacher, Dieter, Steinemann, Dori, Hahnen, Eric, Kast, Karin, Arnold, Norbert, Varon-Mateeva, Raymonda, Wand, Dorothea, Godwin, Andrew K., Evans, D.Gareth, Frost, Debra, Perkins, Jo, Adlard, Julian, Izatt, Louise, Platte, Radka, Eeles, Ro, Ellis, Steve, Hamann, Ute, Garber, Judy, Fostira, Florentia, Fountzilas, George, Pasini, Barbara, Giannini, Giuseppe, Rizzolo, Piera, Russo, Antonio, Cortesi, Laura, Papi, Laura, Varesco, Liliana, Palli, Domenico, Zanna, Ine, Savarese, Antonella, Radice, Paolo, Manoukian, Siranoush, Peissel, Bernard, Barile, Monica, Bonanni, Bernardo, Viel, Alessandra, Pensotti, Valeria, Tommasi, Stefania, Peterlongo, Paolo, Weitzel, Jeffrey N., Osorio, Ana, Benitez, Javier, McGuffog, Lesley, Healey, Sue, Gerdes, Anne-Marie, Ejlertsen, Bent, Hansen, Thomas V.O., Steele, Linda, Ding, Yuan Chun, Tung, Nadine, Janavicius, Ramuna, Goldgar, David E., Buys, Saundra S., Daly, Mary B., Bane, Anita, Terry, Mary Beth, John, Esther M., Southey, Melissa, Easton, Douglas F., Chenevix-Trench, Georgia, Antoniou, Antonis C., Ottini, Laura |
Rok vydání: | 2016 |
Předmět: |
Male
0301 basic medicine Genotype-phenotype correlation Pathology genotype-phenotype correlations endocrine system diseases Settore MED/06 - Oncologia Medica FEATURES male breast cancer Genotype-phenotype correlations Logistic regression Histologic grade 610 Medical sciences Medicine Breast cancer 0302 clinical medicine Epidemiology Medicine and Health Sciences polycyclic compounds skin and connective tissue diseases POPULATION RISK education.field_of_study BRCA1 Protein Men Single Nucleotide Middle Aged 3. Good health GRADE 030220 oncology & carcinogenesis Male breast cancer oncology Female Breast Neoplasm Research Article Human Adult medicine.medical_specialty CARCINOMA Genotype–phenotype correlations 3122 Cancers Population Breast Neoplasms BRCA1/2 histologic grade pathology cancer research Male breast cancer BRCA1 BRCA2 Polymorphism Single Nucleotide Càncer de mama Breast Neoplasms Male 03 medical and health sciences SDG 3 - Good Health and Well-being Journal Article Carcinoma medicine Humans Genetic Predisposition to Disease Polymorphism education Aged Neoplasm Staging BRCA2 Protein business.industry Odds ratio medicine.disease Confidence interval 030104 developmental biology ddc:161 Homes Mutation Oncology Cancer Research business |
Zdroj: | Breast Cancer Research, 18. BioMed Central Ltd. Silvestri, V, Barrowdale, D, Mulligan, A M, Neuhausen, S L, Fox, S, Karlan, B Y, Mitchell, G, James, P, Thull, D L, Zorn, K K, Carter, N J, Nathanson, K L, Domchek, S M, Rebbeck, T R, Ramus, S J, Nussbaum, R L, Olopade, O I, Rantala, J, Yoon, S-Y, Caligo, M A, Spugnesi, L, Bojesen, A, Pedersen, I S, Thomassen, M, Jensen, U B, Toland, A E, Senter, L, Andrulis, I L, Glendon, G, Hulick, P J, Imyanitov, E N, Greene, M H, Mai, P L, Singer, C F, Rappaport-Fuerhauser, C, Kramer, G, Vijai, J, Offit, K, Robson, M, Lincoln, A, Jacobs, L, Machackova, E, Foretova, L, Navratilova, M, Vasickova, P, Couch, F J, Hallberg, E, Ruddy, K J, Sharma, P, Kim, S-W & kConFab Investigators 2016, ' Male breast cancer in BRCA1 and BRCA2 mutation carriers : pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 ', Breast Cancer Research (Online), vol. 18, no. 1, 15 . https://doi.org/10.1186/s13058-016-0671-y Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid Consejería de Sanidad de la Comunidad de Madrid Silvestri, V; Barrowdale, D; Mulligan, AM; Neuhausen, SL; Fox, S; Karlan, BY; et al.(2016). Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2. BREAST CANCER RESEARCH, 18. doi: 10.1186/s13058-016-0671-y. UCLA: Retrieved from: http://www.escholarship.org/uc/item/63r387vc Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname Silvestri, V, Barrowdale, D, Mulligan, A M, Neuhausen, S L, Fox, S, Karlan, B Y, Mitchell, G, James, P, Thull, D L, Zorn, K K, Carter, N J, Nathanson, K L, Dornchek, S M, Rebbeck, T R, Ramus, S J, Nussbaum, R L, Olopade, O I, Rantala, J, Yoon, S-Y, Caligo, M A, Spugnesi, L, Bojesen, A, Pedersen, I S, Thomassen, M, Jensen, U B, Toland, A E, Senter, L, Andrulis, I L, Glendon, G, Hulick, P J, Irnyanitov, E N, Greene, M H, Mai, P L, Singer, C F, Rappaport-Fuerhauser, C, Kramer, G, Vijai, J, Offit, K, Robson, M, Lincoln, A, Jacobs, L, Machackova, E, Foretova, L, Navratilova, M, Vasickova, P, Couch, F J, Hallberg, E, Ruddy, K J, Sharma, P, Kim, S-W, Hereditary Breast Ovarian Canc Res & EMBRACE 2016, ' Male breast cancer in BRCA1 and BRCA2 mutation carriers : pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 ', Breast Cancer Research (Online Edition), vol. 18, no. 15, 15 . https://doi.org/10.1186/s13058-016-0671-y BREAST CANCER RESEARCH Silvestri, V, Barrowdale, D, Mulligan, A M, Neuhausen, S L, Fox, S, Karlan, B Y, Mitchell, G, James, P, Thull, D L, Zorn, K K, Carter, N J, Nathanson, K L, Domchek, S M, Rebbeck, T R, Ramus, S J, Nussbaum, R L, Olopade, O I, Rantala, J, Yoon, S-Y, Caligo, M A, Spugnesi, L, Bojesen, A, Pedersen, I S, Thomassen, M, Jensen, U B, Toland, A E, Senter, L, Andrulis, I L, Glendon, G, Hulick, P J, Imyanitov, E N, Greene, M H, Mai, P L, Singer, C F, Rappaport-Fuerhauser, C, Kramer, G, Vijai, J, Offit, K, Robson, M, Lincoln, A, Jacobs, L, Machackova, E, Foretova, L, Navratilova, M, Vasickova, P, Couch, F J, Hallberg, E, Ruddy, K J, Sharma, P, Gerdes, A-M & kConFab Investigators 2016, ' Male breast cancer in BRCA1 and BRCA2 mutation carriers : pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 ', Breast Cancer Research (Online), vol. 18, 15 . https://doi.org/10.1186/s13058-016-0671-y Silvestri, V, Barrowdale, D, Mulligan, A M, Neuhausen, S L, Fox, S, Karlan, B Y, Mitchell, G, James, P, Thull, D L, Zorn, K K, Carter, N J, Nathanson, K L, Domchek, S M, Rebbeck, T R, Ramus, S J, Nussbaum, R L, Olopade, O I, Rantala, J, Yoon, S-Y, Caligo, M A, Spugnesi, L, Bojesen, A, Pedersen, I S, Thomassen, M, Jensen, U B, Toland, A E, Senter, L, Andrulis, I L, Glendon, G, Hulick, P J, Imyanitov, E N, Greene, M H, Mai, P L, Singer, C F, Rappaport-Fuerhauser, C, Kramer, G, Vijai, J, Offit, K, Robson, M, Lincoln, A, Jacobs, L, Machackova, E, Foretova, L, Navratilova, M, Vasickova, P, Couch, F J, Hallberg, E, Ruddy, K J, Sharma, P, Evans, G & kConFab Investigators 2016, ' Male breast cancer in BRCA1 and BRCA2 mutation carriers : pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 ', Breast Cancer Research, vol. 18, no. 1, 15 . https://doi.org/10.1186/s13058-016-0671-y Silvestri, V, Barrowdale, D, Mulligan, A M, Neuhausen, S L, Fox, S, Karlan, B Y, Mitchell, G, James, P A, Thull, D L, Zorn, K K, Carter, N J, Nathanson, K L, Domchek, S M, Rebbeck, T R, Ramus, S J, Nussbaum, R L, Olopade, O I, Rantala, J, Yoon, S-Y, Caligo, M A, Spugnesi, L, Bojesen, A, Pedersen, I S, Thomassen, M, Jensen, U B, Toland, A E, Senter, L, Andrulis, I L, Glendon, G, Hulick, P J, Imyanitov, E N, Greene, M H, Mai, P L, Singer, C F, Rappaport-Fuerhauser, C, Kramer, G, Vijai, J, Offit, K, Robson, M, Lincoln, A, Jacobs, L, Machackova, E, Foretova, L, Navratilova, M, Vasickova, P, Couch, F J, Hallberg, E, Ruddy, K J, Gerdes, A-M, Hansen, T V O & kConFab Investigators 2016, ' Male breast cancer in BRCA1 and BRCA2 mutation carriers : pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 ', Breast Cancer Research (Online), vol. 18, 15 . https://doi.org/10.1186/s13058-016-0671-y Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Breast Cancer Research : BCR Breast Cancer Research, 18 |
ISSN: | 1465-5411 1465-542X |
Popis: | Background BRCA1 and, more commonly, BRCA2 mutations are associated with increased risk of male breast cancer (MBC). However, only a paucity of data exists on the pathology of breast cancers (BCs) in men with BRCA1/2 mutations. Using the largest available dataset, we determined whether MBCs arising in BRCA1/2 mutation carriers display specific pathologic features and whether these features differ from those of BRCA1/2 female BCs (FBCs). Methods We characterised the pathologic features of 419 BRCA1/2 MBCs and, using logistic regression analysis, contrasted those with data from 9675 BRCA1/2 FBCs and with population-based data from 6351 MBCs in the Surveillance, Epidemiology, and End Results (SEER) database. Results Among BRCA2 MBCs, grade significantly decreased with increasing age at diagnosis (P = 0.005). Compared with BRCA2 FBCs, BRCA2 MBCs were of significantly higher stage (P for trend = 2 × 10−5) and higher grade (P for trend = 0.005) and were more likely to be oestrogen receptor–positive [odds ratio (OR) 10.59; 95 % confidence interval (CI) 5.15–21.80] and progesterone receptor–positive (OR 5.04; 95 % CI 3.17–8.04). With the exception of grade, similar patterns of associations emerged when we compared BRCA1 MBCs and FBCs. BRCA2 MBCs also presented with higher grade than MBCs from the SEER database (P for trend = 4 × 10−12). Conclusions On the basis of the largest series analysed to date, our results show that BRCA1/2 MBCs display distinct pathologic characteristics compared with BRCA1/2 FBCs, and we identified a specific BRCA2-associated MBC phenotype characterised by a variable suggesting greater biological aggressiveness (i.e., high histologic grade). These findings could lead to the development of gender-specific risk prediction models and guide clinical strategies appropriate for MBC management. Electronic supplementary material The online version of this article (doi:10.1186/s13058-016-0671-y) contains supplementary material, which is available to authorized users. |
Databáze: | OpenAIRE |
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