Effects of (60)co whole-body gamma-irradiation in different doses on the distribution of (188)Re-labeled autologous mesenchymal stem cells in wistar rats after intravenous (systemic) transplantation during different periods after exposure
| Autor: | V. M. Petriev, E. V. Agaeva, O. A. Smorizanova, O. A. Konoplyannikova, I. V. Semenkova, S. Sh. Kal’sina, L. A. Lepechina, A. G. Konoplyannikov |
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| Rok vydání: | 2008 |
| Předmět: |
Pathology
medicine.medical_specialty Time Factors Stimulation Mesenchymal Stem Cell Transplantation Radiation Dosage Transplantation Autologous General Biochemistry Genetics and Molecular Biology Medicine Animals Tissue Distribution Cobalt Radioisotopes Rats Wistar Cells Cultured Stem cell transplantation for articular cartilage repair Radioisotopes Induced stem cells business.industry Mesenchymal stem cell Amniotic stem cells Mesenchymal Stem Cells General Medicine Rats Transplantation Rhenium Gamma Rays Injections Intravenous business Whole-Body Irradiation Adult stem cell Homing (hematopoietic) |
| Zdroj: | Bulletin of experimental biology and medicine. 145(4) |
| ISSN: | 0007-4888 |
| Popis: | The effects of whole-body gamma-irradiation in different doses on the distribution of (188)Re-labeled mesenchymal stem cells obtained by culturing of the rat bone marrow cells were studied in different organs and tissues of animals after intravenous (systemic) injection. Irradiation stimulated homing of (188)Re-labeled mesenchymal stem cells in organs and tissues of animals in comparison with this process in intact non-irradiated rats. The intensity of homing increased with increasing the irradiation dose and decreased with prolongation of the period between irradiation and systemic transplantation. It was hypothesized that increased migration of transplanted mesenchymal stem cells into irradiated organs and tissues can be caused by developing cell death processes. It seems that systemic transplantation of mesenchymal stem cells shortly after irradiation can be used for stimulation of reparative processes in damaged tissues. |
| Databáze: | OpenAIRE |
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