Pentazocine increases bispectral index without surgical stimulation during nitrous oxide–sevoflurane anesthesia
| Autor: | Y. Yamanishi, T. Imamura, Jun Shimada, Hiroshi Nagasaka, Satoshi Hagihira, Noriko Onuki, S. Yoshikawa, K. Onuki |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Methyl Ethers Pentazocine medicine.medical_treatment Nitrous Oxide Blood Pressure Fentanyl Sevoflurane Consciousness Monitors Double-Blind Method Heart Rate Heart rate Intubation Intratracheal Humans Medicine Intubation Anesthesia Prospective Studies business.industry Anesthesiology and Pain Medicine Blood pressure Bispectral index Anesthetics Inhalation Female Analysis of variance Vecuronium bromide business Anesthetics Intravenous medicine.drug |
| Zdroj: | Journal of Anesthesia. 25:946-949 |
| ISSN: | 1438-8359 0913-8668 |
| DOI: | 10.1007/s00540-011-1224-2 |
| Popis: | Although there have been a large number of reports on the effects of opioids on the bispectral index (BIS) during anesthesia, the effects of pentazocine on the BIS have not been reported. In this study, 60 patients scheduled for elective oral surgery [30 females, 30 males; all American Society of Anesthesiologists Physical Status (ASA PS) category 1] were enrolled in the trials. Maintaining gender parity, we randomly assigned the patients to one of three groups: pentazocine group (0.3 mg/kg; n = 20), fentanyl group (1 μg/kg; n = 20), or saline group (n = 20); these opioids were administered intravenously 15 min after the intubation. Anesthesia was induced with thiopental and vecuronium bromide and maintained with nitrous oxide (4 l/min)–oxygen (2 l/min)–sevoflurane (1%). At 15 min after the intubation, mean arterial blood pressure (MAP), heart rate (HR), and BIS index were recorded as baseline values. MAP, HR, and BIS values were measured at 2.5-min after the intubation up to 30 min. All data were expressed as the mean ± standard deviation. Differences in BIS values, MAP, and HR among the three groups throughout the experiment were analyzed using two-way repeated-measures analysis of variance (ANOVA), and demographic data among the three groups were analyzed using one-way ANOVA. Post hoc comparisons were performed using Fisher’s protected least significant difference test. A P value of |
| Databáze: | OpenAIRE |
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