The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis
| Autor: | Tatsunobu Fukushima, Shuichi Kaneko, Hitoshi Ando, Seiichiro Kurita, Kosuke R. Shima, Naoto Matsuzawa-Nagata, Akio Fujimura, Masafumi Kumazaki, Hirofumi Misu, Toshinari Takamura, Nakamura Seiji, Naoyuki Togawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Lipid Metabolism Disorder Circadian clock Biophysics Biology Mitochondrion Biochemistry Mice Biological Clocks Internal medicine medicine Animals Clock gene Circadian rhythm Molecular Biology Non-alcoholic steatohepatitis Oligonucleotide Array Sequence Analysis Gene Expression Profiling Fatty liver Lipid metabolism Cell Biology medicine.disease Fatty Liver Mice Inbred C57BL CLOCK Disease Models Animal Endocrinology Liver Oxidative stress Diet Atherogenic Atherogenic diet Steatohepatitis |
| Zdroj: | Biochemical and Biophysical Research Communications. 380(3):684-688 |
| ISSN: | 0006-291X |
| Popis: | 金沢大学医薬保健研究域医学系 Recent studies have correlated metabolic diseases, such as metabolic syndrome and non-alcoholic fatty liver disease, with the circadian clock. However, whether such metabolic changes per se affect the circadian clock remains controversial. To address this, we investigated the daily mRNA expression profiles of clock genes in the liver of a dietary mouse model of non-alcoholic steatohepatitis (NASH) using a custom-made, high-precision DNA chip. C57BL/6J mice fed an atherogenic diet for 5 weeks developed hypercholesterolemia, oxidative stress, and NASH. DNA chip analyses revealed that the atherogenic diet had a great influence on the mRNA expression of a wide range of genes linked to mitochondrial energy production, redox regulation, and carbohydrate and lipid metabolism. However, the rhythmic mRNA expression of the clock genes in the liver remained intact. Most of the circadianly expressed genes also showed 24-h rhythmicity. These findings suggest that the biological clock is protected against such a metabolic derangement as NASH. © 2009 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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