The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY
| Autor: | Nc-Iuphar, David R. Cavanagh, Michael Spedding, Adam J. Pawson, Jamie A. Davies, Anthony P. Davenport, Jane F. Armstrong, Elena Faccenda, Christopher Southan, Simon D. Harding, Joanna L. Sharman, Brice Campo, Stephen P.H. Alexander |
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| Rok vydání: | 2019 |
| Předmět: |
Plasmodium
Databases Factual Databases Pharmaceutical Web Browser Pharmacology Biology Ligands Antimalarials User-Computer Interface 03 medical and health sciences 0302 clinical medicine Drug Discovery Genetics medicine Database Issue Humans Molecular Targeted Therapy 030304 developmental biology 0303 health sciences Web browser Molecular interactions Drug discovery medicine.disease Immunopharmacology Malaria 3. Good health Molecular targets Software 030217 neurology & neurosurgery |
| Zdroj: | Armstrong, J, Faccenda, E, Harding, S, Pawson, A, Southan, C, Sharman, J, Campo, B, Cavanagh, D, Alexander, S P H, Davenport, A P, Spedding, M, Davies, J & IUPHAR, NC 2019, ' The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY ', Nucleic Acids Research . https://doi.org/10.1093/nar/gkz951 Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | The IUPHAR/BPS Guide to PHARMACOLOGY (www.guidetopharmacology.org) is an open-access, expert-curated database of molecular interactions between ligands and their targets. We describe significant updates made over the seven releases during the last two years. The database is notably enhanced through the continued linking of relevant pharmacology with key immunological data types as part of the IUPHAR Guide to IMMUNOPHARMACOLOGY (www.guidetoimmunopharmacology.org) and by a major new extension, the IUPHAR/MMV Guide to Malaria PHARMACOLOGY (www.guidetomalariapharmacology.org). The latter has been constructed in partnership with the Medicines for Malaria Venture, an organization dedicated to identifying, developing and delivering new antimalarial therapies that are both effective and affordable. This is in response to the global challenge of over 200 million cases of malaria and 400 000 deaths worldwide, with the majority in the WHO Africa Region. It provides new pharmacological content, including molecular targets in the malaria parasite, interaction data for ligands with antimalarial activity, and establishes curation of data from screening assays, used routinely in antimalarial drug discovery, against the whole organism. A dedicated portal has been developed to provide quick and focused access to these new data. |
| Databáze: | OpenAIRE |
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