Burkholderia cepacia meningitis in the Central African Republic
| Autor: | Anne Le Flèche-Matéos, Pierre-Alain Rubbo, Alain Farra, Thierry Frank, Hugues Sanke, Alain Berlioz-Arthaud, Jean-Pierre Lombart, Jean-Robert Mbecko |
|---|---|
| Přispěvatelé: | Service de bactériologie [Bangui], Institut Pasteur de Bangui, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Environnement et Risques infectieux - Environment and Infectious Risks (ERI), Institut Pasteur [Paris], Institut Pasteur [Paris] (IP) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
MESH: Meningitis
Bacterial / drug therapy Imipenem MESH: Burkholderia Infections / drug therapy [SDV]Life Sciences [q-bio] 030231 tropical medicine Ceftazidime MESH: Anti-Bacterial Agents / pharmacology Burkholderia cepacia MESH: Anti-Bacterial Agents / administration & dosage Letter to the Editors antibiotics Microbiology 03 medical and health sciences 0302 clinical medicine MESH: RNA Ribosomal 16S / genetics [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Bacteriology Medicine Meningitis MESH: Burkholderia Infections / microbiology 030212 general & internal medicine Neck stiffness [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases MESH: Humans biology business.industry Mortality rate MESH: Child Preschool Outbreak [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology General Medicine MESH: Drug Resistance Multiple Bacterial medicine.disease biology.organism_classification MESH: Meningitis Bacterial / diagnosis MESH: Male 3. Good health MESH: Burkholderia Infections / diagnosis Central African Republic Burkholderia MESH: Central African Republic MESH: Meningitis Bacterial / microbiology MESH: Burkholderia cepacia / isolation & purification business medicine.drug |
| Zdroj: | The Pan African Medical Journal The Pan African Medical Journal, Pan African Medical Center for Public Health Research and Information, 2019, 32, pp.12. ⟨10.11604/pamj.2019.32.12.16552⟩ The Pan African Medical Journal, 2019, 32, pp.12. ⟨10.11604/pamj.2019.32.12.16552⟩ |
| ISSN: | 1937-8688 |
| DOI: | 10.11604/pamj.2019.32.12.16552⟩ |
| Popis: | International audience; Burkholderia cepacia causes frequent infections in immunocompromised and hospitalized patients, with a significant mortality rate. This bacterial species has also been associated with epidemic outbreaks due to contamination of antiseptic solutions and parenteral and nebulized medications. In 2016, in the town of Bongonon in the north of the Central African Republic (CAR), a three-year-old boy with febrile meningeal syndrome (fever, neck stiffness and altered general condition) was admitted for a medical consultation provided by the nongovernmental organization MSF-Spain. On 20 March 2016, a sample of the boy's cerebrospinal fluid was sent to the Bacteriology Laboratory of the Pasteur Institute of Bangui for analysis. Conventional bacteriology showed that the isolate was a Gram-negative bacillus, which was identified as B. cepacia by using API 20 NE, with 99.9%confidence. In addition, the strain presented an acquired resistance to ticarcillin-clavulanate, ceftazidime and imipenem but remained susceptible to cotrimoxazole. As B. cepacia had never previously been isolated from cerebrospinal fluid in Africa, we chose to identify the strain by 16S rRNA gene sequencing. The molecular data showed that the isolate belonged to B. cepacia group. This is the first report of a case of meningitis caused by B. cepacia in CAR and developing countries. |
| Databáze: | OpenAIRE |
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