T2∗ magnetic resonance imaging: A non-invasive biomarker of brain iron content in children with attention-deficit/hyperactivity disorder
| Autor: | Mohamed Sarhan, Germeen Albair Ashamalla, Mohamed El-Assmy, Amal Abdelsattar Sakrana, Sieza Samir, Bothina Mohamed Hasaneen |
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| Jazyk: | angličtina |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty lcsh:R895-920 Gastroenterology behavioral disciplines and activities 03 medical and health sciences 0302 clinical medicine Thalamus 030225 pediatrics Internal medicine Healthy control mental disorders Brain iron medicine Attention deficit hyperactivity disorder ADHD Radiology Nuclear Medicine and imaging Psychiatry Inattentive type medicine.diagnostic_test business.industry Non invasive biomarkers Adhd group Magnetic resonance imaging medicine.disease R2∗ measurements T2∗-MRI Radiology Nuclear Medicine and imaging Iron content Radiology business 030217 neurology & neurosurgery |
| Zdroj: | The Egyptian Journal of Radiology and Nuclear Medicine, Vol 48, Iss 1, Pp 161-167 (2017) |
| ISSN: | 0378-603X |
| DOI: | 10.1016/j.ejrnm.2016.08.001 |
| Popis: | Purpose The aims of this study were the followings: First: To compare brain iron content in children with Attention-Deficit/Hyperactivity Disorder (ADHD) and healthy control subjects, estimated by T2 ∗ MRI value and its reciprocal R2 ∗ . Second: To assess the association between brain iron content and distinct types of ADHD (predominantly inattentive, predominantly hyperactive/impulsive, or combined). Third: To test the ability of T2 ∗ MRI to grade the severity of ADHD. Patients and methods 35 children (17 ADHD patients and 18 healthy non-ADHD controls) underwent T2 ∗ -MRI to assess brain iron content. R2 ∗ value is calculated for both thalami. Results ADHD group showed significantly lower R2 ∗ (mean 14.9 s −1 ± 1.3) value when compared to control group (mean R2 ∗ 16.6 s −1 ± 0.9) ( p = ∗ was 15.65 s −1 , and R2 ∗ less than 15.65 s −1 showed good AUC for prediction of ADHD. Combined ADHD type showed significantly lower R2 ∗ when compared to inattentive type ( p = 0.033 respectively). No significant correlations were found between R2 ∗ value and severity of ADHD. Conclusion T2 ∗ MRI represents a reliable non-invasive tool for probing brain iron contents. Lower R2 ∗ values correlate with ADHD type but not with ADHD severity. |
| Databáze: | OpenAIRE |
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