Modulation of incisor eruption in rats by sympathetic efferents
| Autor: | Elie D. Al Chaer, Khaldoun Rifai, Jose Johann Chidiac, Nayef E. Saadé, Ammar Kassab |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Sympathetic Nervous System Ganglionic Blockers Mandibular Nerve medicine.medical_treatment Tooth eruption Mandible Inferior alveolar nerve Hexamethonium Tooth Eruption Rats Sprague-Dawley Lesion 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Incisor Internal medicine medicine Animals Sympathectomy General Dentistry Guanethidine Denervation business.industry 030206 dentistry Cell Biology General Medicine Rats stomatognathic diseases medicine.anatomical_structure Endocrinology Otorhinolaryngology chemistry Female medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Archives of Oral Biology. 89:31-36 |
| ISSN: | 0003-9969 |
| DOI: | 10.1016/j.archoralbio.2018.02.003 |
| Popis: | Intact neural supply is necessary for tooth eruption. Sympathetic denervation accelerates or decelerates the eruption rate depending on the tooth condition (intact or injured). The aim of this study is to reexamine the role of the sympathetic innervation, through the observation of the effects of pre or post ganglionic chemical sympathectomy on the eruption of intact rat incisors.Different groups of rats were subjected to either ganglionic or peripheral chemical sympathectomy and the observed effects on incisor eruption were compared to those made on intact/sham groups or on rats subjected to inferior alveolar nerve (IAN) lesion.The total amount of eruption in control/naïve rats, measured over a total period of 144 h, was 3 ± 0.15 mm and decreased to 2.57 ± 0.06 mm (n = 8; p 0.01) or 2.8 ± 0.10 mm (n = 8; p 0.05) following treatment with guanethidine and hexamethonium, respectively. This amount decreased to 1.8 ± 0.14 mm (p 0.001 vs. control, n = 7; or p 0.01 vs. sham, n = 5) in rats subjected to IAN lesion.Sympathectomy delayed tooth eruption. Blocking the sympathetic effectors with guanethidine exerted more potent effects than ganglionic block with hexamethonium. Intact sympathetic supply is required for tooth growth under normal conditions. |
| Databáze: | OpenAIRE |
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