Combined effects of moderate exercise and short-term fasting on markers of immune function in healthy human subjects
| Autor: | Karsten Krueger, Klaus Eder, Robert Ringseis, Behzad Hajizadeh Maleki, Frank C. Mooren, Kerstin Conrad, Katharina Alack, Gerhard Liebisch |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Leptin Male 0301 basic medicine medicine.medical_specialty Physiology Thiobarbituric acid Lymphocyte medicine.medical_treatment Apoptosis Inflammation Thiobarbituric Acid Reactive Substances Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Physiology (medical) Internal medicine medicine TBARS Humans Insulin Exercise Chemokine CCL2 Interleukin-6 Tumor Necrosis Factor-alpha business.industry Fasting 030229 sport sciences Healthy Volunteers Oxidative Stress 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Tumor necrosis factor alpha medicine.symptom business Biomarkers |
| Zdroj: | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 318:R1103-R1115 |
| ISSN: | 1522-1490 0363-6119 |
| DOI: | 10.1152/ajpregu.00341.2019 |
| Popis: | This study aimed to investigate the effects of a short-term (36 h) fasting period combined with an acute bout of exercise on markers of immune function and inflammation in healthy human subjects. Fourteen moderately trained male subjects (aged 19–39 yr) participated in a 36-h fasting trial (FA-T), followed by an acute bout of moderate exercise (60% V̇o2max). After 1 wk, the same subjects, as their own control, participated in a nonfasting trial (NFA-T) in which they performed an exercise trial of the same duration and intensity. Blood samples were taken before, immediately after, and 1 h after each exercise bout and analyzed for several immunological and metabolic markers. At baseline, fasting subjects showed lower levels of T cell apoptosis, lymphocyte-proliferative responses, IL-6, monocyte chemoattractant protein-1 (MCP-1), insulin, and leptin ( P < 0.05) as well as higher levels of neutrophil oxidative burst and thiobarbituric acid reactive substances (TBARS) than those in the NFA-T ( P < 0.05). After the exercise protocol, fasted subjects revealed higher T cell apoptosis, neutrophil oxidative burst, TBARS, TNFα, and MCP-1 levels as well as lower levels of lymphocyte-proliferative response, IL-6, insulin, and leptin than those in the NFA-T ( P < 0.05). Short-term fasting aggravates perturbations in markers of immune function, and inflammation was induced by an acute moderate-intensity exercise protocol. |
| Databáze: | OpenAIRE |
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