From strawberry gingivitis to palatal perforation: The clinicopathological spectrum of oral mucosal lesions in granulomatosis with polyangiitis
| Autor: | Nathalia Targa Pinto, Silvia Vanessa Lourenço, Marcello Menta Simonsen Nico |
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| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
medicine.medical_specialty Disease Antibodies Antineutrophil Cytoplasmic Pathology and Forensic Medicine Lesion 03 medical and health sciences 0302 clinical medicine medicine Humans Oral mucosa Retrospective Studies Palate business.industry Granulomatosis with Polyangiitis Retrospective cohort study 030206 dentistry medicine.disease Gingivitis Dermatology medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Localized disease Palatal perforation Periodontics Oral Surgery medicine.symptom Strawberry gingivitis Granulomatosis with polyangiitis business |
| Zdroj: | Journal of Oral Pathology & Medicine. 49:443-449 |
| ISSN: | 1600-0714 0904-2512 |
| DOI: | 10.1111/jop.13008 |
| Popis: | BACKGROUND Reports of oral manifestations of granulomatosis with polyangiitis (GPA) usually refer to single-case reports; "strawberry gingivitis" has been increasingly reported. OBJECTIVE To study the clinicopathological findings of four patients in which the diagnosis of GPA was suspected from the observation of their oral lesions and compare these to existent data. METHODS Retrospective study of a case series. RESULTS One patient presented typical "strawberry gingivitis" with localized disease and negative ANCA results. Two patients presented rapidly growing oral ulcers associated with systemic compromise and high ANCA levels. One patient presented with a chronic granulomatous lesion that leaded to palatal perforation. CONCLUSION Oral manifestations of GPA may vary from rapidly evolving lesions in acutely ill patients to chronic and locally destructive lesions in slowing developing disease. These differences are also evident in the histopathological findings. |
| Databáze: | OpenAIRE |
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