Potential Biomarker Peptides Associated with Acute Alcohol-Induced Reduction of Blood Pressure
| Autor: | Ichiro Wakabayashi, Lyang-Ja Lee, Mikio Marumo, Tomoko Shimomura, Katsuhiko Hatake, Daisuke Nonaka, Ryoji Eguchi, Tanaka Kenji |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Physiology Glycobiology lcsh:Medicine Alcohol Peptide Blood Pressure Wine Fibrinogen Vascular Medicine Biochemistry Mass Spectrometry Analytical Chemistry chemistry.chemical_compound 0302 clinical medicine Spectrum Analysis Techniques Allergies Medicine and Health Sciences 030212 general & internal medicine lcsh:Science Fibrinogen alpha chain chemistry.chemical_classification Multidisciplinary Alcohol Consumption Complement C4 Venous blood Hematology Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Middle Aged Body Fluids Chemistry Blood Hypertension Physical Sciences Anatomy Anaphylaxis medicine.drug Research Article Adult medicine.medical_specialty Alcohol Drinking Immunology Research and Analysis Methods 03 medical and health sciences Internal medicine medicine Humans Nutrition Glycoproteins Ethanol lcsh:R Biology and Life Sciences Blood Pressure Determination medicine.disease Peptide Fragments Diet Blood pressure Endocrinology chemistry lcsh:Q Clinical Immunology Clinical Medicine Peptides 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 1, p e0147297 (2016) |
| ISSN: | 1932-6203 |
| Popis: | The purpose of this study was to explore the peptides that are related to acute reduction of blood pressure after alcohol drinking. Venous blood was collected from male healthy volunteers before and after drinking white wine (3 ml/kg weight) containing 13% of ethanol. Peptidome analysis for serum samples was performed using a new target plate, BLOTCHIP®. Alcohol caused significant decreases in systolic and diastolic blood pressure levels at 45 min. The peptidome analysis showed that the levels of three peptides of m/z 1467, 2380 and 2662 changed significantly after drinking. The m/z 1467 and 2662 peptides were identified to be fragments of fibrinogen alpha chain, and the m/z 2380 peptide was identified to be a fragment of complement C4. The intensities of the m/z 2380 and m/z 1467 peptides before drinking were associated with % decreases in systolic and diastolic blood pressure levels at 45 min after drinking compared with the levels before drinking, while there were no significant correlations between the intensity of the m/z 2662 peptide and % decreases in systolic and diastolic blood pressure levels after drinking. The m/z 1467 and 2380 peptides are suggested to be markers for acute reduction of blood pressure after drinking alcohol. |
| Databáze: | OpenAIRE |
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