Pathomechanisms in schwannoma development and progression
| Autor: | Helen Morrison, Alexander Schulz, Dario-Lucas Helbing |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cancer microenvironment
0301 basic medicine Cancer Research Cell type Review Article Biology Schwannoma law.invention Extracellular matrix 03 medical and health sciences Mice 0302 clinical medicine law otorhinolaryngologic diseases Genetics medicine Animals Humans Molecular Biology Inflammation Tumor microenvironment medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Peripheral nervous system Cancer research Disease Progression Suppressor Intracellular Neurilemmoma |
| Zdroj: | Oncogene |
| ISSN: | 1476-5594 |
| Popis: | Schwannomas are tumors of the peripheral nervous system, consisting of different cell types. These include tumorigenic Schwann cells, axons, macrophages, T cells, fibroblasts, blood vessels, and an extracellular matrix. All cell types involved constitute an intricate “tumor microenvironment” and play relevant roles in the development and progression of schwannomas. Although Nf2 tumor suppressor gene-deficient Schwann cells are the primary tumorigenic element and principle focus of current research efforts, evidence is accumulating regarding the contributory roles of other cell types in schwannoma pathology. In this review, we aim to provide an overview of intra- and intercellular mechanisms contributing to schwannoma formation. “Genes load the gun, environment pulls the trigger.” -George A. Bray |
| Databáze: | OpenAIRE |
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