Phthalate exposure during pregnancy and long-term weight gain in women
Autor: | Martha María Téllez-Rojo, Belem Trejo-Valdivia, Deborah J. Watkins, Karen E. Peterson, Lourdes Schnaas, John D. Meeker, Katherine Svensson, Alejandra Cantoral, Maritsa Solano, Yanelli Rodríguez-Carmona |
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Rok vydání: | 2018 |
Předmět: |
Adult
Breastfeeding Phthalic Acids Physiology 010501 environmental sciences Weight Gain 01 natural sciences Biochemistry Article Body Mass Index 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Pregnancy Medicine Humans Women 030212 general & internal medicine Child Mexico 0105 earth and related environmental sciences General Environmental Science business.industry Weight change Phthalate Environmental exposure Environmental Exposure Anthropometry medicine.disease chemistry Maternal Exposure General Earth and Planetary Sciences Gestation Environmental Pollutants Female medicine.symptom business Body mass index Weight gain |
Zdroj: | Environmental research. 169 |
ISSN: | 1096-0953 |
Popis: | Background Phthalates are known endocrine disruptors and peroxisome proliferator-activated receptor (PPAR) activators, potentially capable of promoting an obesogenic effect. Pregnant women are especially vulnerable to phthalate exposure due to physiological and metabolic changes during pregnancy, including those related to the metabolism of xenobiotics. Phthalate exposure during pregnancy has been associated with early gestational weight gain, however, its effect on long-term weight gain remains unclear. The aim of the present study was to evaluate the association between phthalate exposure during pregnancy and long-term changes in weight among women. Methods Urinary phthalate concentrations, socioeconomic, anthropometry and information on diet and socioeconomic status were collected during pregnancy from 178 women from the Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) birth cohort. Maternal body weight and diet information was also collected up to 5 times in the first year postpartum and twice during follow-up visits 5.2–10.7 years later. A path analysis was performed to assess associations between urinary phthalate metabolite levels during pregnancy and change in weight (kg) per year after delivery, including age, education, living with/without partner, parity, daily energy intake and breastfeeding duration. Results The mean age at pregnancy was 27.3 ± 5.9 years and mean body mass index during the first postpartum year was 27.07 ± 4.22 kg/m2. On average, women gained 3.48 kg (0.52 ± 0.84 kg/year). A unit increase in log-transformed mono-3-carboxypropyl phthalate (MCPP) was associated with 0.33 kg (95% CI: 0.09, 0.56) higher weight gain per year, and mono-benzyl phthalate (MBzP) with 0.21 kg (95% CI: −0.38, −0.03) lower weight gain per year. Conclusion Exposure to certain phthalates during pregnancy may be associated with long-term weight change in women. More studies on the effects of phthalate exposure during pregnancy on women's long-term health are required. |
Databáze: | OpenAIRE |
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