Chitin and chitosan stimulate canine polymorphonuclear cells to release leukotriene B4 and prostaglandin E2
| Autor: | Takahiro Takayama, Yoshihiro Shigemasa, Saburo Minami, Yoshiharu Okamoto, Yasuyuki Usami |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Blood Platelets
Male Erythrocytes Neutrophils Leukotriene B4 Biomedical Engineering Biocompatible Materials Chitin macromolecular substances In Vitro Techniques Biology Dinoprostone Microbiology Biomaterials Chitosan chemistry.chemical_compound Dogs In vivo Leukocytes medicine Animals Prostaglandin E2 hemic and immune systems Exudates and Transudates In vitro respiratory tract diseases carbohydrates (lipids) Chemotaxis Leukocyte chemistry Biochemistry Liberation Female Arachidonic acid circulatory and respiratory physiology medicine.drug |
| Zdroj: | Journal of Biomedical Materials Research. 42:517-522 |
| ISSN: | 1097-4636 0021-9304 |
| DOI: | 10.1002/(sici)1097-4636(19981215)42:4<517::aid-jbm6>3.0.co;2-u |
| Popis: | The effects of chitin and chitosan on the release of arachidonic acid products were investigated in this study. Supernatants of canine polymorphonuclear cell (PMN) suspensions incubated with chitin and chitosan contained a leukotriene B4 (LTB4) concentration high enough to induce canine PMN migration in vitro. The supernatants also contained the same concentration of prostaglandin E2 (PGE2) as that normally found in the peripheral blood of dogs. Intraperitoneal administration of chitosan to dogs induced peritoneal exudative fluid (PEF), but chitin did not. The PEF contained numerous PMNs and macrophages. The supernatant of PEF contained both heat-stable and heat-labile chemotactic factors for canine PMNs. It also contained enough LTB4 to attract the canine PMNs in vitro. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text