Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat
| Autor: | Gloria E. Villalpando-Rodriguez, Spencer B. Gibson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Aging
Programmed cell death Cell signaling Necroptosis Cell Review Article Biology Biochemistry medicine Animals Humans chemistry.chemical_classification Reactive oxygen species QH573-671 Cell Death Mechanism (biology) Cell Biology General Medicine Cell biology Crosstalk (biology) medicine.anatomical_structure chemistry Apoptosis Cytology Reactive Oxygen Species Signal Transduction |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | Reactive oxygen species (ROS) are essential for cellular signaling and response to stress. The level of ROS and the type of ROS determine the ability of cells to undergo cell death. Furthermore, dysregulation of the antioxidant pathways is associated with many diseases. It has become apparent that cell death can occur through different mechanisms leading to the classifications of different types of cell death such as apoptosis, ferroptosis, and necroptosis. ROS play essential roles in all forms of cell death, but it is only now coming into focus that ROS control and determine the type of cell death that occurs in any given cell. Indeed, ROS may act as a rheostat allowing different cell death mechanisms to be engaged and crosstalk with different cell death types. In this review, we will describe the ROS regulatory pathways and how they control different types of cell death under normal and disease states. We will also propose how ROS could provide a mechanism of crosstalk between cell death mechanisms and act as a rheostat determining the type of cell death. |
| Databáze: | OpenAIRE |
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