Alcohol impairs auditory processing of frequency changes and novel sounds: a combined MEG and EEG study
| Autor: | Hidehisa Yamashita, Essi Marttinen Rossi, Seppo Kähkönen |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Involuntary attention Pharmacology toxicology Mismatch negativity Alcohol Electroencephalography Audiology behavioral disciplines and activities P3a chemistry.chemical_compound Double-Blind Method medicine Humans Attention Pitch Perception Pharmacology Cross-Over Studies medicine.diagnostic_test Ethanol Central Nervous System Depressants Magnetoencephalography Electrophysiology chemistry Acoustic Stimulation Data Interpretation Statistical Auditory Perception Evoked Potentials Auditory Female Psychology psychological phenomena and processes Algorithms |
| Zdroj: | Psychopharmacology. 177(4) |
| ISSN: | 0033-3158 |
| Popis: | Alcohol has been shown to impair involuntary attention studied by event-related potentials using mismatch negativity (MMN) and P3a.However, no studies have investigated whether alcohol affects the magnetic counterparts of N1 (N1m), MMN (MMNm) and P3a (P3am).Auditory evoked potentials and magnetic fields elicited by infrequent deviant tones differing in frequency (5% and 20% change) and novel sounds were recorded with whole-head magnetoencephalography (MEG) and electroencephalography (EEG). Stimuli were presented separately to the left and right ear. Eleven right-handed subjects were studied in a double-blind, placebo-controlled (0.8 g/kg ethanol or juice), cross-over design. N1m, MMNm, and P3am were calculated from the channel pair at the temporal cortex showing the strongest responses in the hemisphere contralateral to the stimulation. N1, MMN and P3a were analyzed from 12 electrodes at the midline frontocentral area.Alcohol reduced bilaterally N1, N1m, MMN and MMNm amplitudes. P3a amplitudes, but not P3am amplitudes were also significantly decreased. No effects of alcohol on the latencies of N1, MMN and P3a or their magnetic counterparts were observed.Alcohol impairs the processing of tones, frequency change and novel sounds at different phases of auditory processing similarly in both hemispheres. MEG provides us with additional information unobtainable with EEG about the effects of alcohol on the neural correlates of cognition. |
| Databáze: | OpenAIRE |
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