Exposure to acute levels of waterborne aluminium modifies the legacy of early life stage irradiation, including the communication of radiation-induced bystander signals, in adult rainbow trout
| Autor: | Richard D. Moccia, Richard W. Smith, Rohin Saroya, Colin Seymour, Carmel Mothersill |
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| Rok vydání: | 2015 |
| Předmět: |
Gill
Radiation Dosage Radiation Tolerance Toxicology Andrology Bystander effect medicine Animals Radiology Nuclear Medicine and imaging Yolk sac Life Cycle Stages Radiological and Ultrasound Technology biology Aquatic animal Dose-Response Relationship Radiation Environmental exposure Bystander Effect Environmental Exposure biology.organism_classification Trout medicine.anatomical_structure Oncorhynchus mykiss Toxicity Rainbow trout Water Pollutants Chemical Aluminum |
| Zdroj: | International journal of radiation biology. 91(11) |
| ISSN: | 1362-3095 |
| Popis: | To determine if the legacy of early life stage irradiation seen in rainbow trout is modified in adult fish by acute exposure to waterborne aluminium (Al).Two-year-old trout which had been irradiated as either eggs 48 h after fertilization, eyed eggs, yolk sac larvae or as first feeders, were exposed to 100 or 200 μg l(-1) Al. These fish were then paired with untreated fish. Gill and skin samples from both the irradiated and Al-exposed, and the untreated bystander fish, were then assayed for the production of toxic or pro-death signals, using the HPV-G reporter cell line.Depending on the life stage, irradiated and the tissue assayed acute Al exposure modified both the radiation legacy, and the radiation-induced bystander effect in untreated fish, either by reducing reporter cell survival or increasing reporter cell growth.The effects of early irradiation and adult Al exposure were complex but clearly demonstrated that both the direct radiation effects and the communication of a radiation-induced bystander effect can be modified by a second environmental stressor. |
| Databáze: | OpenAIRE |
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