Procalcitonin, C-reactive protein, and endotoxin after bone marrow transplantation: identification of children at high risk of morbidity and mortality from sepsis
| Autor: | B. Gruhn, D. Fuchs, K. Tiede, D Berger, Felix Zintl, Martin Sauer |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Calcitonin Male medicine.medical_specialty Adolescent Calcitonin Gene-Related Peptide Multiple Organ Failure Neutropenia Gastroenterology Procalcitonin Sepsis Risk Factors Germany Internal medicine medicine Humans Prospective Studies Protein Precursors Child Prospective cohort study Bone Marrow Transplantation Transplantation Leukopenia biology Septic shock business.industry C-reactive protein Infant Hematology Prognosis medicine.disease Shock Septic Surgery Endotoxins C-Reactive Protein Child Preschool biology.protein Female medicine.symptom business Complication |
| Zdroj: | Bone Marrow Transplantation. 31:1137-1142 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/sj.bmt.1704045 |
| Popis: | We prospectively evaluated the capacity of serum procalcitonin (PCT), compared with serum levels of C-reactive protein (CRP) and endotoxin, to identify children at high risk for mortality from sepsis after BMT. Of 47 pediatric bone marrow transplantation patients studied, 22 had an uneventful course post-transplant (Group 1), 17 survived at least one septic event (Group 2), and eight died from multiorgan failure (MOF) following septic shock (Group 3). Median concentrations of PCT over the course of the study were 1.3, 15.2, and 102.8 ng/ml, respectively, in each of the three groups (P |
| Databáze: | OpenAIRE |
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