Damage and recovery assessment of the mouse jejunum to abdominal X-ray and adriamycin treatment
| Autor: | S. Lesher, L L Schenken, R. F. Hagemann, J. W. Cooper, D R Burholt |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Crypt
Pharmacology Radiation Dosage digestive system Lethal Dose 50 Mice Mouse Jejunum Animals Medicine Radiology Nuclear Medicine and imaging business.industry Cell growth X-ray Drug dosages General Medicine Proliferative response Radiation Effects Radiation exposure Jejunum medicine.anatomical_structure Doxorubicin Abdomen Female business Nuclear medicine Cell Division |
| Zdroj: | The British Journal of Radiology. 48:908-912 |
| ISSN: | 1748-880X 0007-1285 |
| DOI: | 10.1259/0007-1285-48-575-908 |
| Popis: | The influence of adriamycin on the post-irradiation proliferative response of the mouse jejunum was examined. Doses of either 5 or 10 mg/kg of adriamycin administered immediately after abdominal irradiation reduced the LD50/7 days by 300–400 R. Neither dosage of the drug reduced the number of surviving crypts, as measured by the crypt isolation and microcolony techniques, for a given radiation exposure. However, both drug dosages reduced the amount of post-irradiation compensatory hyperplasia, as measured by 3H-thymidine incorporation. |
| Databáze: | OpenAIRE |
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