Elevated lysine crotonylation and succinylation in the brains of BTBR mice
| Autor: | Rongshan Li, Hongen Wei, Min Wang, Chunfang Wang, Fengyun Hu, Yongfeng Liu, Qiaoqiao Chang, Hua Yang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Central nervous system Lysine Biology Mice Mice Neurologic Mutants 03 medical and health sciences Succinylation 0302 clinical medicine Species Specificity Developmental Neuroscience medicine Animals Social Behavior 030304 developmental biology Brain Chemistry Cerebral Cortex 0303 health sciences Brain Succinates Cell biology Mice Inbred C57BL Blot medicine.anatomical_structure Cerebral cortex Crotonates Female Protein Processing Post-Translational 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | International Journal of Developmental Neuroscience. 76:61-64 |
| ISSN: | 1873-474X 0736-5748 |
| Popis: | The BTBR T + Itpr3tf/J (BTBR) mouse has developmental disorders in the central nervous system and many aberrant neuroanatomical structures. However, identification of the pathological mechanisms underlying these abnormal neuroanatomical structures in the brains of BTBR mice is still lacking. Posttranslational modifications (PTMs) are known to be involved in the regulation of diverse cellular processes, and evidence shows that some types of PTMs are associated with the development of the central nervous system. In this study, we detected four novel PTMs in the cerebral cortex of BTBR mice as compared to C57BL/6 J (B6) mice using western blotting. Results revealed that lysine crotonylation and succinylation were elevated in the cerebral cortex of BTBR mice compared to levels in B6 mice. We speculate that elevated profiles of lysine crotonylation and succinylation may be involved in mechanisms related to neuroanatomical abnormalities in cerebral cortex of BTBR mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text