The intake of grain fibers modulates cytokine levels in blood

Autor:	Roel Vermeulen, Salvatore Panico, Franco Berrino, S. H. Fatemeh, Toby J. Athersuch, Domenico Palli, Carlotta Sacerdote, Shu Chun Chuang, Vittorio Krogh, Rosario Tumino, Paolo Vineis, Mansour T. A. Sharabiani
Rok vydání:	2011
Předmět:	Adult Dietary Fiber Male Chemokine Health Toxicology and Mutagenesis medicine.medical_treatment Clinical Biochemistry Physiology Inflammation Biology Biochemistry Cohort Studies Immune system Surveys and Questionnaires medicine Humans Fiber Aged Middle Aged Diet Cross-Sectional Studies Cytokine Italy Case-Control Studies Cohort Immunology biology.protein Cytokines Female Digestive tract Dietary fiber medicine.symptom Edible Grain
Zdroj:	Biomarkers. 16:504-510
ISSN:	1366-5804 1354-750X
Popis:	Dietary fiber may modulate the environment of the intestinal lumen, alter the intestinal microflora populations, and influence the immune response and disease risk. Epidemiological investigations have suggested that higher fiber intake is associated with lower overall mortality, in particular from cardiovascular and digestive tract diseases. Here a panel of 17 cytokines and chemokines were measured in plasma of 88 cancer-free subjects sampled within the Italian EPIC-Italy cohort. A statistically significant inverse association (p-trend = 0.01) was observed for cereal fiber and cytokines included in the main factor in factor analysis (IL-1β, IL-4, IL-5, IL-6, IL-13, and TNF-α), which alone explained 35.5% of variance. Our study suggests that fiber intake, especially cereal fiber, may be associated with a decreased level of pro-inflammatory cytokines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e45185c468df8c385c21b8574b8c8e https://doi.org/10.3109/1354750x.2011.599042 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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