Topical lambda-cyhalothrin in reducing eye oscillations in a canine model of infantile nystagmus syndrome

Autor:	Richard W. Hertle, Louis F. Dell'Osso, Dongsheng Yang, Michelle Evano-Chapman, Jeffery Dumire, Jonathan B. Jacobs
Rok vydání:	2020
Předmět:	Retinal degeneration medicine.medical_specialty Intraocular pressure Eye Movements genetic structures eye-drop treatment Nystagmus Extraocular muscles Nystagmus Pathologic chemistry.chemical_compound Dogs infantile nystagmus Ophthalmology Nitriles Pyrethrins Animals Humans Medicine Proprioception business.industry medicine.disease eye diseases Cyhalothrin medicine.anatomical_structure RPE65 chemistry Canine nystagmus Original Article sense organs medicine.symptom business Nystagmus Congenital Canine model
Zdroj:	Indian Journal of Ophthalmology
ISSN:	0301-4738
DOI:	10.4103/ijo.ijo_586_20
Popis:	Purpose: To determine the ocular and systemic safety of using topical Lambda-Cyhalothrin (LCL) in a canine model of infantile nystagmus syndrome (INS). The rationale for this proposal is based on a case study of a patient whose INS improved after inadvertent ocular exposure to a pyrethroid pesticide containing LCL. Methods: After in-vitro safety testing and IUCAC approval, we studied increasing concentrations of topical LCL drops (0.002% to 0.07%) in canines with a purposely bred defect in the RPE65 gene resulting in both retinal degeneration and INS. We collected data on ocular and systemic effects and performed eye-movement recordings (EMR). Results: At the 0.07% concentration dose of LCL, there was minimal, reversible, conjunctival hyperemia. There was no other ocular or systemic toxicity. At the 0.06% dose, there was a visible decrease in the INS and EMR showed a 153%–240% increase in the nystagmus acuity function and a 30%–70% decrease in amplitude across gaze. There was also a 40%–60% decrease in intraocular pressure while on the drop in both eyes. Conclusion: This animal study suggests this new pharmacological agent has potential for topical treatment of both INS and diseases with raised intraocular pressure. Further, this new treatment approach confirms the importance of extraocular muscle proprioception in ocular motor diseases and their treatment.
Databáze:	OpenAIRE
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