Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infections
| Autor: | Catherine Royer, Hervé Lefèvre, Catherine Lacombe, Florence Moulin, Pierre Palmer, Mathie Lorrot, Claude Bohuon, Josette Raymond, Sylvie Guerin, Joël Coste, Sophie Ravilly, Dominique Gendrel |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Calcitonin
Microbiology (medical) congenital hereditary and neonatal diseases and abnormalities Adolescent Calcitonin Gene-Related Peptide medicine.medical_treatment Alpha interferon Sensitivity and Specificity Procalcitonin Predictive Value of Tests parasitic diseases Humans Medicine Protein Precursors Child Interleukin 6 Interferon alfa Immunoassay biology medicine.diagnostic_test Interleukin-6 business.industry C-reactive protein Infant Interferon-alpha Bacterial Infections bacterial infections and mycoses C-Reactive Protein Infectious Diseases Cytokine ROC Curve Virus Diseases Child Preschool Luminescent Measurements Pediatrics Perinatology and Child Health Immunology biology.protein Viral disease Emergency Service Hospital business Biomarkers hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The Pediatric Infectious Disease Journal. 18:875-881 |
| ISSN: | 0891-3668 |
| Popis: | Procalcitonin (PCT) concentration increases in bacterial infections but remains low in viral infections and inflammatory diseases. The change is rapid and the molecule is stable, making it a potentially useful marker for distinguishing between bacterial and viral infections.PCT concentration was determined with an immunoluminometric assay on plasma collected at admission in 360 infants and children hospitalized for bacterial or viral infection. It was compared with C-reactive protein (CRP), interleukin 6 and interferon-alpha measured on the same sample.The mean PCT concentration was 46 microg/l (median, 17.8) in 46 children with septicemia or bacterial meningitis. PCT concentration was1 microg/l in 44 of 46 in this group and in 59 of 78 children with a localized bacterial infection who had a negative blood culture (sensitivity, 83%). PCT concentration was1 microg/l in 16 of 236 children with a viral infection (specificity, 93%). PCT concentration was low in 9 of 10 patients with inflammatory disease and fever. A CRP valueor =20 mg/l was observed in 61 of 236 patients (26%) with viral infection and in 105 of 124 patients (86%) with bacterial infection. IL-6 was100 pg/ml in 14% of patients infected with virus and in 53% with bacteria. A secretion of interferon-alpha was found in serum in 77% of viral infected patients and in 8.6% of bacterial infected patients.In this study a PCT value of 1 microg/l or greater had better specificity, sensitivity and predictive value than CRP, interleukin 6 and interferon-alpha in children for distinguishing between viral and bacterial infections. PCT values are higher in invasive bacterial infections, but the cutoff value of 1 microg/l indicates the severity of the disease in localized bacterial infection and helps to decide antibiotic treatment in emergency room. PCT may be useful in an emergency room for differentiation of bacterial vs. viral infections in children and for making decisions about antibiotic treatments. |
| Databáze: | OpenAIRE |
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