Prejunctional actions of some β-adrenoceptor antagonists in the vas deferens preparation of the guinea-pig
| Autor: | C. Raper, E. J. Mylecharane |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Guanethidine
Male medicine.medical_specialty Dextroamphetamine Adrenergic beta-Antagonists Guinea Pigs Adrenergic Stimulation Propranolol In Vitro Techniques Pharmacology Guinea pig Norepinephrine Vas Deferens Cocaine Internal medicine medicine Animals Anilides Chemistry Vas deferens Articles Pronethalol Amino Alcohols Electric Stimulation Blockade medicine.anatomical_structure Endocrinology Ethanolamines Sympatholytics Sulfonic Acids medicine.drug |
| Zdroj: | British Journal of Pharmacology. 39:128-138 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1970.tb09562.x |
| Popis: | 1. The β-adrenoceptor antagonists propranolol, pronethalol, MJ 1999 and Ciba 39089-Ba reduced responses to field stimulation of the guinea-pig isolated vas deferens preparation without significantly affecting responses to exogenously added noradrenaline. 2. This prejunctional blocking action of the drugs cannot be correlated with their action as β-adrenoceptor antagonists or non-specific depressants. 3. The blockade produced was more pronounced at low (5-20 Hz) than at high (50 Hz) frequencies of stimulation. 4. The blockade was slow in onset, and once established was poorly reversed by washing the preparation over a period of 1 to 2 h. 5. The blockade produced could be reversed by dexamphetamine and cocaine. 6. These experiments suggest that the β-adrenoceptor antagonists may have some actions which closely resemble those of the adrenergic neurone blocking agent guanethidine. |
| Databáze: | OpenAIRE |
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