Evidence for Involvement of Wnt Signalling in Body Polarities, Cell Proliferation, and the Neuro-Sensory System in an Adult Ctenophore
| Autor: | Hervé Le Guyader, Antoine Mialot, Michaël Manuel, Cyrielle Dayraud, Muriel Jager, Eric Quéinnec |
|---|---|
| Přispěvatelé: | Phylogénie, Anatomie, Evolution (PAE), Evolution Paris Seine, Université des Antilles et de la Guyane (UAG)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles et de la Guyane (UAG)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), ``Agence Nationale de la Recherche' ANR [ANR-09-BLAN-0236 DiploDevo], Institut Universitaire de France (IUF), Université des Antilles et de la Guyane (UAG)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles et de la Guyane (UAG)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (... - 2019) (UNS) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Anatomy and Physiology
Body Patterning Animal Evolution lcsh:Medicine 0302 clinical medicine Cell polarity Morphogenesis Nervous System Physiological Phenomena Pattern Formation Cloning Molecular Comparative Anatomy lcsh:Science Wnt Signaling Pathway In Situ Hybridization 0303 health sciences Multidisciplinary biology Ctenophora Stem Cells Wnt signaling pathway Cell Differentiation Cell biology Adult Stem Cells France Stem cell Neural development Research Article Cell type animal structures [SDV.BID]Life Sciences [q-bio]/Biodiversity Neurological System 03 medical and health sciences Animals Biology 030304 developmental biology Cell Proliferation Evolutionary Biology Evolutionary Developmental Biology Gene Expression Profiling lcsh:R Computational Biology Molecular Development Body Plan Organization biology.organism_classification Embryonic stem cell Signaling Organismal Evolution Morphogens Neuroanatomy Gene Expression Regulation Microscopy Fluorescence Microscopy Electron Scanning lcsh:Q Organism Development Zoology 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, 2013, 8 (12), pp.e84363. ⟨10.1371/journal.pone.0084363⟩ PLoS ONE, Vol 8, Iss 12, p e84363 (2013) PLoS ONE, Public Library of Science, 2013, 8 (12), pp.e84363. ⟨10.1371/journal.pone.0084363⟩ |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0084363⟩ |
| Popis: | International audience; Signalling through the Wnt family of secreted proteins originated in a common metazoan ancestor and greatly influenced the evolution of animal body plans. In bilaterians, Wnt signalling plays multiple fundamental roles during embryonic development and in adult tissues, notably in axial patterning, neural development and stem cell regulation. Studies in various cnidarian species have particularly highlighted the evolutionarily conserved role of the Wnt/b-catenin pathway in specification and patterning of the primary embryonic axis. However in another key non-bilaterian phylum, Ctenophora, Wnts are not involved in early establishment of the body axis during embryogenesis. We analysed the expression in the adult of the ctenophore Pleurobrachia pileus of 11 orthologues of Wnt signalling genes including all ctenophore Wnt ligands and Fz receptors and several members of the intracellular b-catenin pathway machinery. All genes are strongly expressed around the mouth margin at the oral pole, evoking the Wnt oral centre of cnidarians. This observation is consistent with primary axis polarisation by the Wnts being a universal metazoan feature, secondarily lost in ctenophores during early development but retained in the adult. In addition, local expression of Wnt signalling genes was seen in various anatomical structures of the body including in the locomotory comb rows, where their complex deployment suggests control by the Wnts of local comb polarity. Other important contexts of Wnt involvement which probably evolved before the ctenophore/ cnidarian/bilaterian split include proliferating stem cells and progenitors irrespective of cell types, and developing as well as differentiated neuro-sensory structures. |
| Databáze: | OpenAIRE |
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