Effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters and serum oxidative stress markers in fructose-induced diabetic Wistar rats
| Autor: | Nnenna Princess Nwankwo, Idongesit Kokoabasi Paul Isong, Inyene Gordon Udofia, Iya Eze Bassey, Uwem Okon Akpan, DE Ikpi, Chibuzor Charles Onyeukwu |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Physiology medicine.medical_treatment chemistry.chemical_element 030209 endocrinology & metabolism Context (language use) Ascorbic Acid Fructose Calcium medicine.disease_cause Antioxidants Diabetes Mellitus Experimental 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Diabetes mellitus Internal medicine medicine Animals Vitamin E Magnesium Rats Wistar Vitamin C General Medicine Vitamins medicine.disease Rats Oxidative Stress Endocrinology chemistry 030220 oncology & carcinogenesis Dietary Supplements Oxidative stress Biomarkers |
| Zdroj: | Archives of physiology and biochemistry. 128(3) |
| ISSN: | 1744-4160 |
| Popis: | Context: Deleterious effects of diabetes on seminal quality, serum metals and antioxidants have been confirmed.Objective: This study evaluated the effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters, serum total antioxidant capacity (TAC), nitric oxide (NO), malonyldialdehyde (MDA), calcium and magnesium in fructose-induced diabetic rats.Materials and methods: Thirty rats were grouped into non-diabetic controls, diabetic controls, diabetic rats given vitamin E + C, calcium + magnesium and vitamin E + C + calcium + magnesium. The analytes were evaluated using standard methods. Statistical significance was set at p < .05.Results: The diabetic controls had significantly higher MDA (p = .036) but lower (p = .0001) TAC, calcium, magnesium, sperm count, and %motility than the non-diabetic controls. The Vitamin C + E group showed the greatest improvement as they had the highest values of seminal parameters compared to other supplemented groups.Conclusion: Combined Vitamin C + E supplementation may provide better ameliorative benefits than a combination of Vitamin C, E, calcium and magnesium in diabetics. |
| Databáze: | OpenAIRE |
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