Exhaled nitric oxide correlates with airway eosinophils in childhood asthma
| Autor: | Jeremy Lyons, Madeleine Ennis, P.S. Fitch, T. J. Warke, Vanessa Brown, Michael D. Shields, R. Taylor |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Nitric Oxide Sensitivity and Specificity Nitric oxide chemistry.chemical_compound Humans Medicine Expiration Child Asthma Eosinophil cationic protein medicine.diagnostic_test business.industry respiratory system Eosinophil medicine.disease respiratory tract diseases Eosinophils medicine.anatomical_structure Bronchoalveolar lavage Breath Tests ROC Curve chemistry Immunology Exhaled nitric oxide Original Article Female business Bronchoalveolar Lavage Fluid Biomarkers Respiratory tract |
| Zdroj: | Warke, T, Fitch, P S, Brown, V, Taylor, R, Lyons, J D, Ennis, M & Shields, M 2002, ' Exhaled nitric oxide correlates with airway eosinophils in childhood asthma ' Thorax, vol. 57, no. 5, pp. 383-387 . DOI: 10.1136/thorax.57.5.383 |
| ISSN: | 0040-6376 |
| DOI: | 10.1136/thorax.57.5.383 |
| Popis: | Background: Exhaled nitric oxide has been proposed as a marker for airway inflammation in asthma. The aim of this study was to compare exhaled nitric oxide levels with inflammatory cells and mediators in bronchoalveolar lavage fluid from asthmatic and normal children. Methods: Children were recruited from elective surgical lists and a non-bronchoscopic bronchoalveolar lavage (BAL) was performed after induction of anaesthesia. Exhaled nitric oxide (parts per billion) was measured by two techniques: tidal breathing and restricted breath. Results: Median (interquartile range) exhaled nitric oxide measured by restricted breath was increased in asthmatics compared with normal children (24.3 (10.5–66.5) v 9.7 (6.5–16.5), difference between medians 14.6 (95% CI 5.1 to 29.9), p=0.001). In asthmatic children exhaled nitric oxide correlated significantly with percentage eosinophils (r=0.78, pConclusions: Exhaled nitric oxide correlates closely with percentage eosinophils in BAL fluid in asthmatic children and is therefore likely to be a useful non-invasive marker of airway inflammation. |
| Databáze: | OpenAIRE |
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