Self-assembly of a 5-fluorouracil-dipeptide hydrogel

Autor:	Mark W. Grinstaff, Jonah A. Kaplan, Jon R. Parquette, Carlo M. Croce, Yuan Sun, Hui-Lung Sun, Aileen Shieh
Rok vydání:	2016
Předmět:	Antimetabolites Antineoplastic Cell Survival 02 engineering and technology 010402 general chemistry 01 natural sciences Catalysis chemistry.chemical_compound Cell Line Tumor Neoplasms Polymer chemistry Materials Chemistry medicine Humans Dipeptide Chemistry Metals and Alloys Hydrogels Dipeptides General Chemistry 021001 nanoscience & nanotechnology 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Human tumor Fluorouracil Cell culture Delayed-Action Preparations Nanofiber Self-healing hydrogels Ceramics and Composites Biophysics Self-assembly 0210 nano-technology medicine.drug Conjugate
Zdroj:	Chemical Communications. 52:5254-5257
ISSN:	1364-548X 1359-7345
Popis:	The self-assembly of 5-fluorouracil dilysine conjugates into self-supporting hydrogels, comprised of entangled nanofibers or rigid nanotubes with diameters of 10 and 16 nm, respectively, is reported. The rate of release of 5-Fu from the conjugates was highly dependent on concentration in solution, whereas, release from the fully formed hydrogels was significantly slower. The 5-Fu conjugate also exhibited promising in vitro cytotoxicity against human tumor cell lines A549, H460 and H23.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d7b25ae3ad0abef661164e18c1b990 https://doi.org/10.1039/c6cc01195k Zobrazit plný text záznamu