Acute Kidney Injury Associated With Lopinavir/Ritonavir Combined Therapy in Patients With COVID-19

Autor: Jean-Paul Mira, Hafsah Hachad, Yannick Binois, Julien Charpentier, Jean-Daniel Chiche, Frédéric Pène, Lee S. Nguyen, Bénédicte Lebrun-Vignes, Joe-Elie Salem, Alain Cariou
Přispěvatelé: Gestionnaire, Hal Sorbonne Université, Unité de Soins Intensifs [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre d'investigation clinique Biothérapie [CHU Pitié-Salpêtrière] (CIC-BTi), Centre d'investigation clinique pluridisciplinaire [CHU Pitié Salpêtrière] (CIC-P 1421), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre d'investigation clinique Paris Est [CHU Pitié Salpêtrière] (CIC Paris-Est), Epidemiology in Dermatology and Evaluation in Therapeutics (EpiDermE), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Ambroise Paré [AP-HP], CIC Pitié BT, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CIC Paris Est, Centre d'investigation clinique Paris Est (CIC Paris-Est)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
medicine.medical_specialty
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
030232 urology & nephrology
Lopinavir/ritonavir
030204 cardiovascular system & hematology
lcsh:RC870-923
[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology
Article
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Internal medicine
medicine
In patient
[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
business.industry
Acute kidney injury
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
[SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology
3. Good health
Nephrology
[SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
Combined therapy
business
medicine.drug
Zdroj: Kidney International Reports
Kidney International Reports, In press, ⟨10.1016/j.ekir.2020.07.035⟩
Kidney International Reports, Elsevier, In press, ⟨10.1016/j.ekir.2020.07.035⟩
Kidney International Reports, Vol 5, Iss 10, Pp 1787-1790 (2020)
ISSN: 2468-0249
DOI: 10.1016/j.ekir.2020.07.035⟩
Popis: International audience; Lopinavir and low-dose ritonavir (LPV/RTV) are associated in a fixed-dose combination protease inhibitor therapy used in patients with HIV and AIDS. The recent outbreak of severe acute respiratory syndrome coronavirus 2 infections causing coronavirus disease 2019 (COVID-19) has rekindled the interest in LPV/RTV after preclinical studies.1 Although no benefit was observed with LPV/RTV treatment beyond standard care,2 other randomized controlled trials, such as DisCoVeRy (NCT04315948), are currently enrolling. Like other antiretroviral therapies, LPV/RTV has been previously associated with acute kidney injuries (AKIs), even though no systematic pharmacovigilance analysis was ever performed.We first describe a small case series of AKI associated with LPV/RTV in the course of COVID-19 treatment. We then performed a query in the World Health Organization pharmacovigilance database, VigiBase, and extracted all AKIs associated with LPV/RTV. We then presented clinical characteristics of these events and performed a comparison between HIV and COVID-19 indication in VigiBase.
Databáze: OpenAIRE
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