Rational use of the PFA-100 device for screening of platelet function disorders and von Willebrand disease
| Autor: | Suleyman Cuneyt Karakus, Nilgun Sayinalp, Serafettin Kirazli, Semra Dündar, Hakan Goker, Yahya Buyukasik, O.I. Özcebe, Ibrahim C. Haznedaroglu, Düzgün Özatli |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Platelet Function Tests Sensitivity and Specificity Gastroenterology Predictive Value of Tests hemic and lymphatic diseases Internal medicine medicine Von Willebrand disease Coagulopathy Humans Platelet Diagnostic Equipment business.industry PFA-100 Decision Trees Case-control study Hematology General Medicine medicine.disease von Willebrand Diseases Endocrinology Epinephrine Clotting time Case-Control Studies Predictive value of tests business Algorithms Thrombasthenia medicine.drug |
| Zdroj: | Blood Coagulation & Fibrinolysis. 13:349-353 |
| ISSN: | 0957-5235 |
| DOI: | 10.1097/00001721-200206000-00011 |
| Popis: | Two hundred and five patients referred for evaluation of platelet functions and 126 healthy controls were tested with the PFA-100 instrument. A cut-off value of 150 s for collagen/epinephrine (CEPI) closure time (CT) produced most acceptable sensitivity (90%), specificity (85.2%), and positive (82.6%) and negative (91.6%) predictivity values for screening of platelet function disorders and von Willebrand disease (vWD). All patients with vWD and Glanzmann thrombasthenia could be detected by PFA-100. Both CEPI and collagen/adenosine diphosphate (CADP) CTs were elevated in all of these cases. Sensitivity of the device was 81.6% for patients with platelet secretion defects. CADP CT was normal in 63.9% of the patients in this subgroup. Specificity (47%) and positive predictivity (57%) of the instrument were diminished in patients with low hemoglobin concentrations. Depending on the results, an algorithm was developed for screening of platelet function disorders and vWD with PFA-100. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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