Insights into the dN/dS ratio heterogeneity between brain specific genes and widely expressed genes in species of different complexity
| Autor: | Soumita Podder, Sandip Chakraborty, Tapash Chandra Ghosh, Kakali Biswas |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Biology Regulatory region Evolution Molecular 03 medical and health sciences Mutation Rate Species Specificity Gene Duplication Databases Genetic Genetics Animals Humans Selection Genetic Databases Protein Gene 3' Untranslated Regions Gene sets Brain Genetic Variation Proteins Introns Duplicated genes MicroRNAs 030104 developmental biology Gene Expression Regulation Functional divergence |
| Zdroj: | Genomics. 108(1) |
| ISSN: | 1089-8646 |
| Popis: | In mammals, it has long been suggested that brain-specific genes (BSGs) and widely expressed genes (WEGs) have seemingly lower dN/dS ratio than any other gene sets. However, to what extent these genes differ in their dN/dS ratio has still remained controversial. Here, we have revealed lower dN/dS ratio of BSGs than WEGs in human-mouse, human-orangutan, human-chimpanzee and mouse-rat orthologous pair. The significance level of dN/dS ratio difference indicates a trend of decreasing difference as complexity of compared pairs increases. Further studies with the human-mouse pair revealed that, removal of the duplicated genes from both the dataset has nullified this difference which dictates a vital role of duplicated genes in governing the selection pressure. Conclusively, higher paralog number, expression level, and longer regulatory region length of BSGs allow fewer nucleotide substitutions within them. Our results show for the first time to our knowledge lower dN/dS ratio of BSGs than WEGs. |
| Databáze: | OpenAIRE |
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