Pinofuranoxins A and B, Bioactive Trisubstituted Furanones Produced by the Invasive Pathogen Diplodia sapinea
| Autor: | Antonio Evidente, Marco Masi, Lucia Maddau, Stefano Superchi, Giulia Marsico, Benedetto Teodoro Linaldeddu, Roberta Di Lecce |
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| Přispěvatelé: | Masi, Marco, Di Lecce, Roberta, Marsico, Giulia, Linaldeddu, Benedetto Teodoro, Maddau, Lucia, Superchi, Stefano, Evidente, Antonio |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Athelia rolfsii
Phytophthora Tunisia Plant Disease Pharmaceutical Science Analytical Chemistry Microbiology Quercus Phytophthora cambivora Hedera helix Ascomycota Diplodia sapinea Drug Discovery Furan Animals Quercu Furans Pathogen Plant Diseases Pharmacology Phaseolus biology Molecular Structure Animal Chemistry Hedera Basidiomycota Organic Chemistry Phaseolu biology.organism_classification Note Fungicides Industrial Complementary and alternative medicine Molecular Medicine Artemia salina Artemia Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of Natural Products |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Two new bioactive trisubstituted furanones, named pinofuranoxins A and B (1 and 2), were isolated from Diplodia sapinea, a worldwide conifer pathogen causing severe disease. Pinofuranoxins A and B were characterized essentially by NMR and HRESIMS spectra, and their relative and absolute configurations were assigned by NOESY experiments and computational analyses of electronic circular dichroism spectra. They induced necrotic lesions on Hedera helix L., Phaseolus vulgaris L., and Quercus ilex L. Compound 1 completely inhibited the growth of Athelia rolfsii and Phytophthora cambivora, while 2 showed antioomycetes activity against P. cambivora. In the Artemia salina assay both toxins showed activity inducing larval mortality. |
| Databáze: | OpenAIRE |
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