A double edged-sword - The Complement System during SARS-CoV-2 infection

Autor: Lourdes Isaac, Lazara Elena Santiesteban-Lores, Lorena Bavia, Tiago Francisco da Silva, Thais Akemi Amamura, Leonardo Moura Midon, Milena Carvalho Carneiro
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
viruses
Complement System
Inflammation
Review Article
medicine.disease_cause
Severe Acute Respiratory Syndrome
030226 pharmacology & pharmacy
Asymptomatic
General Biochemistry
Genetics and Molecular Biology
Proinflammatory cytokine
CITOCINAS
03 medical and health sciences
0302 clinical medicine
Pharmacotherapy
medicine
Animals
Humans
General Pharmacology
Toxicology and Pharmaceutics
Complement Activation
Coronavirus
business.industry
SARS-CoV-2
fungi
virus diseases
COVID-19
General Medicine
Complement C3
Complement System Proteins
Acquired immune system
medicine.disease
Complement system
COVID-19 Drug Treatment
030104 developmental biology
Complement Inactivating Agents
Severe acute respiratory syndrome-related coronavirus
Immunology
Middle East Respiratory Syndrome Coronavirus
medicine.symptom
business
Cytokine storm
Complement inhibitors
Coronavirus Infections
Cytokine Release Syndrome
Zdroj: Life Sciences
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1879-0631
0024-3205
Popis: In the past 20 years, infections caused by coronaviruses SARS-CoV, MERS-CoV and SARS-CoV-2 have posed a threat to public health since they may cause severe acute respiratory syndrome (SARS) in humans. The Complement System is activated during viral infection, being a central protagonist of innate and acquired immunity. Here, we report some interactions between these three coronaviruses and the Complement System, highlighting the central role of C3 with the severity of these infections. Although it can be protective, its role during coronavirus infections seems to be contradictory. For example, during SARS-CoV-2 infection, Complement System can control the viral infection in asymptomatic or mild cases; however, it can also intensify local and systemic damage in some of severe COVID-19 patients, due to its potent proinflammatory effect. In this last condition, the activation of the Complement System also amplifies the cytokine storm and the pathogenicity of coronavirus infection. Experimental treatment with Complement inhibitors has been an enthusiastic field of intense investigation in search of a promising additional therapy in severe COVID-19 patients.
Graphical abstract Unlabelled Image
Databáze: OpenAIRE
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