Core Antibiotic-Induced Transcriptional Signatures Reflect Susceptibility to All Members of an Antibiotic Class
| Autor: | Melanie A Martinsen, Alexis Jaramillo Cartagena, Roby P. Bhattacharyya |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Genetics 0303 health sciences Susceptibility testing 030306 microbiology medicine.drug_class Aminoglycoside Antibiotics Microbial Sensitivity Tests Computational biology Biology Early Therapy beta-Lactams Phenotype Anti-Bacterial Agents 03 medical and health sciences Infectious Diseases Antibiotic resistance Susceptibility medicine Pharmacology (medical) Organism 030304 developmental biology |
| Zdroj: | Antimicrob Agents Chemother |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Current growth-based antibiotic susceptibility testing (AST) is too slow to guide early therapy. We previously developed a diagnostic approach that quantifies antibiotic-induced transcriptional signatures to distinguish susceptible from resistant isolates, providing phenotypic AST 24-36h faster than current methods. Here, we show that 10 transcripts optimized for AST of one fluoroquinolone, aminoglycoside, or beta-lactam reflect susceptibility to other members of that class. This finding will streamline development and implementation of this strategy, facilitating efficient antibiotic deployment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|