Effects of KW-3902, an Adenosine A1-Receptor Antagonist, on Ascites Volume in Puromycin Aminonucleoside (PAN)-Induced Nephrotic Rats
| Autor: | Hideaki Kusaka, Akira Karasawa, Ken Nagashima |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
Trichlormethiazide medicine.medical_specialty Sodium Chloride Symporter Inhibitors medicine.medical_treatment Nephrosis Puromycin Aminonucleoside Adenosine A1 receptor Furosemide Internal medicine Edema medicine Animals Rats Wistar Diuretics Pharmacology business.industry Antagonist Ascites medicine.disease Adenosine Rats Endocrinology Purinergic P1 Receptor Antagonists Xanthines medicine.symptom Diuretic business medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 68:213-216 |
| ISSN: | 0021-5198 |
| DOI: | 10.1254/jjp.68.213 |
| Popis: | We investigated the effects of KW-3902 (8-(noradamantan-3-yl)-1, 3-dipropylxanthine), a potent adenosine A1-receptor antagonist, on the nephrotic edema induced by puromycin aminonucleoside (PAN; 100 mg/kg, i.v.) in rats. The treatment with PAN decreased urine volume and urinary excretions of sodium and potassium, resulting in the ascites formation in 7 days. In rats with the nephrosis, KW-3902 (0.01-1 mg/kg/day for 3 days, p.o.) showed diuretic effects and reduced the volume of ascites, as was the case with furosemide (30 mg/kg/day) and trichlormethiazide (1 mg/kg/day). These results suggest that even in the nephrotic state, the adenosine A1-receptor antagonist can be an effective diuretic to ameliorate edema. |
| Databáze: | OpenAIRE |
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